Anti-CXL10/ CXCL10/ C7 functional antibody

Anti-CXL10/ CXCL10/ C7 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CXCL10/CXCL10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T30635-Ab-1/ GM-Tg-hg-T30635-Ab-2Anti-Human CXCL10 monoclonal antibodyHuman
GM-Tg-rg-T30635-Ab-1/ GM-Tg-rg-T30635-Ab-2Anti-Rat CXCL10 monoclonal antibodyRat
GM-Tg-mg-T30635-Ab-1/ GM-Tg-mg-T30635-Ab-2Anti-Mouse CXCL10 monoclonal antibodyMouse
GM-Tg-cynog-T30635-Ab-1/ GM-Tg-cynog-T30635-Ab-2Anti-Cynomolgus/ Rhesus macaque CXCL10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T30635-Ab-1/ GM-Tg-felg-T30635-Ab-2Anti-Feline CXCL10 monoclonal antibodyFeline
GM-Tg-cang-T30635-Ab-1/ GM-Tg-cang-T30635-Ab-2Anti-Canine CXCL10 monoclonal antibodyCanine
GM-Tg-bovg-T30635-Ab-1/ GM-Tg-bovg-T30635-Ab-2Anti-Bovine CXCL10 monoclonal antibodyBovine
GM-Tg-equg-T30635-Ab-1/ GM-Tg-equg-T30635-Ab-2Anti-Equine CXCL10 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T30635-Ab-1/ GM-Tg-hg-T30635-Ab-2; GM-Tg-rg-T30635-Ab-1/ GM-Tg-rg-T30635-Ab-2;
GM-Tg-mg-T30635-Ab-1/ GM-Tg-mg-T30635-Ab-2; GM-Tg-cynog-T30635-Ab-1/ GM-Tg-cynog-T30635-Ab-2;
GM-Tg-felg-T30635-Ab-1/ GM-Tg-felg-T30635-Ab-2; GM-Tg-cang-T30635-Ab-1/ GM-Tg-cang-T30635-Ab-2;
GM-Tg-bovg-T30635-Ab-1/ GM-Tg-bovg-T30635-Ab-2; GM-Tg-equg-T30635-Ab-1/ GM-Tg-equg-T30635-Ab-2
Products NameAnti-CXCL10 monoclonal antibody
Formatmab
Target NameCXCL10
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CXCL10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-168Pre-Made Eldelumab biosimilar, Whole mAb, Anti-CXCL10 Antibody: Anti-C7/IFI10/INP10/IP-10/SCYB10/crg-2/gIP-10/mob-1 therapeutic antibody
    Target AntigenGM-Tg-g-T30635-Ag-1Recombinant multi-species CXL10/ CXCL10/ C7 protein
    CytokineGM-Tg-g-T30635-Ag-1chemokine (C-X-C motif) ligand 10 (CXCL10) protein
    ORF Viral VectorpGMAP000053Human CXCL10 Adenovirus plasmid
    ORF Viral VectorvGMAP000053Human CXCL10 Adenovirus particle
    ORF Viral VectorpGMLP001931human CXCL10 Lentivirus plasmid
    ORF Viral VectorvGMLP001931human CXCL10 Lentivirus particle
    ORF Viral VectorpGMLPm000068mouse Cxcl10 Lentivirus plasmid
    ORF Viral VectorvGMLPm000068mouse Cxcl10 Lentivirus particle


    Target information

    Target IDGM-T30635
    Target NameCXCL10
    Gene ID3627,245920,574243,478432,101100131,615107,100050993
    Gene Symbol and SynonymsC7,crg-2,CXCL10,gIP-10,IFI10,INP10,IP-10,mob-1,SCYB10
    Uniprot AccessionP02778,P48973,Q8MIZ1,Q5KSV9,Q2KIQ8
    Uniprot Entry NameCXL10_HUMAN,CXL10_MACMU,CXL10_RAT,CXL10_CANLF,CXL10_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseBreast Cancer, Complications of kidney transplant, Bacterial sepsis of newborn, Acute kidney failure
    Gene EnsemblENSG00000169245
    Target ClassificationN/A

    The target: CXCL10, gene name: CXCL10, also named as C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1. This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.