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Anti-DNMT3A monoclonal antibody
Pre-made anti-DNMT3A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DNMT3A/DNMT3A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T29355-Ab-1/ GM-Tg-hg-T29355-Ab-2 | Anti-Human DNMT3A monoclonal antibody | Human |
| GM-Tg-rg-T29355-Ab-1/ GM-Tg-rg-T29355-Ab-2 | Anti-Rat DNMT3A monoclonal antibody | Rat |
| GM-Tg-mg-T29355-Ab-1/ GM-Tg-mg-T29355-Ab-2 | Anti-Mouse DNMT3A monoclonal antibody | Mouse |
| GM-Tg-cynog-T29355-Ab-1/ GM-Tg-cynog-T29355-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DNMT3A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T29355-Ab-1/ GM-Tg-felg-T29355-Ab-2 | Anti-Feline DNMT3A monoclonal antibody | Feline |
| GM-Tg-cang-T29355-Ab-1/ GM-Tg-cang-T29355-Ab-2 | Anti-Canine DNMT3A monoclonal antibody | Canine |
| GM-Tg-bovg-T29355-Ab-1/ GM-Tg-bovg-T29355-Ab-2 | Anti-Bovine DNMT3A monoclonal antibody | Bovine |
| GM-Tg-equg-T29355-Ab-1/ GM-Tg-equg-T29355-Ab-2 | Anti-Equine DNMT3A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T29355-Ab-1/ GM-Tg-hg-T29355-Ab-2; GM-Tg-rg-T29355-Ab-1/ GM-Tg-rg-T29355-Ab-2; GM-Tg-mg-T29355-Ab-1/ GM-Tg-mg-T29355-Ab-2; GM-Tg-cynog-T29355-Ab-1/ GM-Tg-cynog-T29355-Ab-2; GM-Tg-felg-T29355-Ab-1/ GM-Tg-felg-T29355-Ab-2; GM-Tg-cang-T29355-Ab-1/ GM-Tg-cang-T29355-Ab-2; GM-Tg-bovg-T29355-Ab-1/ GM-Tg-bovg-T29355-Ab-2; GM-Tg-equg-T29355-Ab-1/ GM-Tg-equg-T29355-Ab-2 |
| Products Name | Anti-DNMT3A monoclonal antibody |
| Format | mab |
| Target Name | DNMT3A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DNMT3A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T29355-Ag-1 | Recombinant multi-species DNM3A/ DNMT3A/ DNMT3A2 protein |
| ORF Viral Vector | pGMLV000064 | human DNMT3A Lentivirus plasmid |
| ORF Viral Vector | pGMAD000315 | human DNMT3A Adenovirus plasmid |
| ORF Viral Vector | vGMLV000064 | human DNMT3A Lentivirus particle |
| ORF Viral Vector | vGMAD000315 | human DNMT3A Adenovirus particle |
| ORF Viral Vector | pGMLPm004779 | mouse Dnmt3a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004779 | mouse Dnmt3a Lentivirus particle |
Target information
| Target ID | GM-T29355 |
| Target Name | DNMT3A |
| Gene ID | 1788,13435,444984,694822,482996,100510798,359716,100055881 |
| Gene Symbol and Synonyms | DNMT3A,DNMT3A2,HESJAS,M.HsaIIIA,MmuIIIA,TBRS |
| Uniprot Accession | Q9Y6K1,Q1LZ53 |
| Uniprot Entry Name | DNM3A_HUMAN,DNM3A_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000119772 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: DNMT3A, gene name: DNMT3A, also named as DNMT3A2, M.HsaIIIA, TBRS. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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