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Anti-MCLN1/ TRPML1/ MCOLN1 monoclonal antibody
Anti-MCLN1/ TRPML1/ MCOLN1 antibody for FACS & in-vivo assay
Go to TRPML1/MCOLN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T28309-Ab-1/ GM-Tg-hg-T28309-Ab-2 | Anti-Human TRPML1/MCOLN1 monoclonal antibody | Human |
| GM-Tg-rg-T28309-Ab-1/ GM-Tg-rg-T28309-Ab-2 | Anti-Rat TRPML1/MCOLN1 monoclonal antibody | Rat |
| GM-Tg-mg-T28309-Ab-1/ GM-Tg-mg-T28309-Ab-2 | Anti-Mouse TRPML1/MCOLN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T28309-Ab-1/ GM-Tg-cynog-T28309-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TRPML1/MCOLN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T28309-Ab-1/ GM-Tg-felg-T28309-Ab-2 | Anti-Feline TRPML1/MCOLN1 monoclonal antibody | Feline |
| GM-Tg-cang-T28309-Ab-1/ GM-Tg-cang-T28309-Ab-2 | Anti-Canine TRPML1/MCOLN1 monoclonal antibody | Canine |
| GM-Tg-bovg-T28309-Ab-1/ GM-Tg-bovg-T28309-Ab-2 | Anti-Bovine TRPML1/MCOLN1 monoclonal antibody | Bovine |
| GM-Tg-equg-T28309-Ab-1/ GM-Tg-equg-T28309-Ab-2 | Anti-Equine TRPML1/MCOLN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T28309-Ab-1/ GM-Tg-hg-T28309-Ab-2; GM-Tg-rg-T28309-Ab-1/ GM-Tg-rg-T28309-Ab-2; GM-Tg-mg-T28309-Ab-1/ GM-Tg-mg-T28309-Ab-2; GM-Tg-cynog-T28309-Ab-1/ GM-Tg-cynog-T28309-Ab-2; GM-Tg-felg-T28309-Ab-1/ GM-Tg-felg-T28309-Ab-2; GM-Tg-cang-T28309-Ab-1/ GM-Tg-cang-T28309-Ab-2; GM-Tg-bovg-T28309-Ab-1/ GM-Tg-bovg-T28309-Ab-2; GM-Tg-equg-T28309-Ab-1/ GM-Tg-equg-T28309-Ab-2 |
| Products Name | Anti-TRPML1/MCOLN1 monoclonal antibody |
| Format | mab |
| Target Name | TRPML1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TRPML1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MCLN1/ TRPML1/ MCOLN1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003780 | human MCOLN1 Lentivirus particle |
| ORF Viral Vector | pGMLP003780 | human MCOLN1 Lentivirus plasmid |
Target information
| Target ID | GM-T28309 |
| Target Name | TRPML1 |
| Gene ID | 57192,94178,288371,703775,611517,101097951,505738,100066441 |
| Gene Symbol and Synonyms | 2210015I05Rik,MCOLN1,MG-2,ML1,ML4,MLIV,MST080,MSTP080,mucolipidin,TRP-ML1,TRPM-L1,TRPML1 |
| Uniprot Accession | Q9GZU1 |
| Uniprot Entry Name | MCLN1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000090674 |
| Target Classification | N/A |
The target: TRPML1, gene name: MCOLN1, also named as MG-2, ML1, ML4, MLIV, MST080, MSTP080, TRP-ML1, TRPM-L1, TRPML1. This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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