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Anti-GDF2/ BMP-9/ BMP9 functional antibody
Anti-GDF2/ BMP-9/ BMP9 functional antibody for cell culture, ELISA & in-vivo assay
Go to GDF2/GDF2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T27611-Ab-1/ GM-Tg-hg-T27611-Ab-2 | Anti-Human GDF2 monoclonal antibody | Human |
| GM-Tg-rg-T27611-Ab-1/ GM-Tg-rg-T27611-Ab-2 | Anti-Rat GDF2 monoclonal antibody | Rat |
| GM-Tg-mg-T27611-Ab-1/ GM-Tg-mg-T27611-Ab-2 | Anti-Mouse GDF2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T27611-Ab-1/ GM-Tg-cynog-T27611-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GDF2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T27611-Ab-1/ GM-Tg-felg-T27611-Ab-2 | Anti-Feline GDF2 monoclonal antibody | Feline |
| GM-Tg-cang-T27611-Ab-1/ GM-Tg-cang-T27611-Ab-2 | Anti-Canine GDF2 monoclonal antibody | Canine |
| GM-Tg-bovg-T27611-Ab-1/ GM-Tg-bovg-T27611-Ab-2 | Anti-Bovine GDF2 monoclonal antibody | Bovine |
| GM-Tg-equg-T27611-Ab-1/ GM-Tg-equg-T27611-Ab-2 | Anti-Equine GDF2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T27611-Ab-1/ GM-Tg-hg-T27611-Ab-2; GM-Tg-rg-T27611-Ab-1/ GM-Tg-rg-T27611-Ab-2; GM-Tg-mg-T27611-Ab-1/ GM-Tg-mg-T27611-Ab-2; GM-Tg-cynog-T27611-Ab-1/ GM-Tg-cynog-T27611-Ab-2; GM-Tg-felg-T27611-Ab-1/ GM-Tg-felg-T27611-Ab-2; GM-Tg-cang-T27611-Ab-1/ GM-Tg-cang-T27611-Ab-2; GM-Tg-bovg-T27611-Ab-1/ GM-Tg-bovg-T27611-Ab-2; GM-Tg-equg-T27611-Ab-1/ GM-Tg-equg-T27611-Ab-2 |
| Products Name | Anti-GDF2 monoclonal antibody |
| Format | mab |
| Target Name | GDF2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GDF2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T27611-Ag-1 | Recombinant multi-species GDF2/ BMP-9/ BMP9 protein |
| Cytokine | GM-Tg-g-T27611-Ag-1 | growth differentiation factor 2 (GDF2) protein |
| ORF Viral Vector | pGMLP002764 | human GDF2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002764 | human GDF2 Lentivirus particle |
| ORF Viral Vector | pGMAAV000354 | house mouse Gdf2 AAV plasmid |
| ORF Viral Vector | pGMLPm001522 | mouse Gdf2 Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000354 | house mouse Gdf2 AAV particle |
| ORF Viral Vector | vGMLPm001522 | mouse Gdf2 Lentivirus particle |
Target information
| Target ID | GM-T27611 |
| Target Name | GDF2 |
| Gene ID | 2658,12165,290921,711516,611149,101087270,540384,100051984 |
| Gene Symbol and Synonyms | BMP-9,BMP9,GDF2,HHT5 |
| Uniprot Accession | Q9UK05 |
| Uniprot Entry Name | GDF2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000263761 |
| Target Classification | N/A |
The target: GDF2, gene name: GDF2, also named as BMP-9, BMP9, HHT5. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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