Anti-IL1R2/ CD121b/ CDw121b monoclonal antibody

Anti-IL1R2/ CD121b/ CDw121b antibody for FACS & in-vivo assay

Target products collectionGo to IL1R2/IL1R2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T23347-Ab-1/ GM-Tg-hg-T23347-Ab-2Anti-Human IL1R2 monoclonal antibodyHuman
GM-Tg-rg-T23347-Ab-1/ GM-Tg-rg-T23347-Ab-2Anti-Rat IL1R2 monoclonal antibodyRat
GM-Tg-mg-T23347-Ab-1/ GM-Tg-mg-T23347-Ab-2Anti-Mouse IL1R2 monoclonal antibodyMouse
GM-Tg-cynog-T23347-Ab-1/ GM-Tg-cynog-T23347-Ab-2Anti-Cynomolgus/ Rhesus macaque IL1R2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T23347-Ab-1/ GM-Tg-felg-T23347-Ab-2Anti-Feline IL1R2 monoclonal antibodyFeline
GM-Tg-cang-T23347-Ab-1/ GM-Tg-cang-T23347-Ab-2Anti-Canine IL1R2 monoclonal antibodyCanine
GM-Tg-bovg-T23347-Ab-1/ GM-Tg-bovg-T23347-Ab-2Anti-Bovine IL1R2 monoclonal antibodyBovine
GM-Tg-equg-T23347-Ab-1/ GM-Tg-equg-T23347-Ab-2Anti-Equine IL1R2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T23347-Ab-1/ GM-Tg-hg-T23347-Ab-2; GM-Tg-rg-T23347-Ab-1/ GM-Tg-rg-T23347-Ab-2;
GM-Tg-mg-T23347-Ab-1/ GM-Tg-mg-T23347-Ab-2; GM-Tg-cynog-T23347-Ab-1/ GM-Tg-cynog-T23347-Ab-2;
GM-Tg-felg-T23347-Ab-1/ GM-Tg-felg-T23347-Ab-2; GM-Tg-cang-T23347-Ab-1/ GM-Tg-cang-T23347-Ab-2;
GM-Tg-bovg-T23347-Ab-1/ GM-Tg-bovg-T23347-Ab-2; GM-Tg-equg-T23347-Ab-1/ GM-Tg-equg-T23347-Ab-2
Products NameAnti-IL1R2 monoclonal antibody
Formatmab
Target NameIL1R2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL1R2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species IL1R2/ CD121b/ CDw121b VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T23347-Ag-1interleukin 1 receptor, type II (IL1R2) protein
    ORF Viral VectorpGMLP000705human IL1R2 Lentivirus plasmid
    ORF Viral VectorvGMLP000705human IL1R2 Lentivirus particle
    ORF Viral VectorpGMAAV000228house mouse Il1r2 AAV plasmid
    ORF Viral VectorpGMLPm002801mouse Il1r2 Lentivirus plasmid
    ORF Viral VectorvGMAAV000228house mouse Il1r2 AAV particle
    ORF Viral VectorvGMLPm002801mouse Il1r2 Lentivirus particle


    Target information

    Target IDGM-T23347
    Target NameIL1R2
    Gene ID7850,16178,117022,711638,481330,101080961,515700,100033831
    Gene Symbol and SynonymsCD121b,CDw121b,IL-1R-2,IL-1R2,IL-1RII,IL-1RT-2,IL-1RT2,Il1r-2,IL1R2,IL1R2c,IL1RB
    Uniprot AccessionP27930,P43303
    Uniprot Entry NameIL1R2_HUMAN,IL1R2_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000115590
    Target ClassificationN/A

    The target: IL1R2, gene name: IL1R2, also named as CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2c, IL1RB, IL1R2. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.