Anti-CCR8/ CC-CKR-8/ CCR-8 monoclonal antibody

Anti-CCR8/ CC-CKR-8/ CCR-8 antibody for FACS & in-vivo assay

Target products collectionGo to CCR8/CCR8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T20575-Ab-1/ GM-Tg-hg-T20575-Ab-2Anti-Human CCR8 monoclonal antibodyHuman
GM-Tg-rg-T20575-Ab-1/ GM-Tg-rg-T20575-Ab-2Anti-Rat CCR8 monoclonal antibodyRat
GM-Tg-mg-T20575-Ab-1/ GM-Tg-mg-T20575-Ab-2Anti-Mouse CCR8 monoclonal antibodyMouse
GM-Tg-cynog-T20575-Ab-1/ GM-Tg-cynog-T20575-Ab-2Anti-Cynomolgus/ Rhesus macaque CCR8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T20575-Ab-1/ GM-Tg-felg-T20575-Ab-2Anti-Feline CCR8 monoclonal antibodyFeline
GM-Tg-cang-T20575-Ab-1/ GM-Tg-cang-T20575-Ab-2Anti-Canine CCR8 monoclonal antibodyCanine
GM-Tg-bovg-T20575-Ab-1/ GM-Tg-bovg-T20575-Ab-2Anti-Bovine CCR8 monoclonal antibodyBovine
GM-Tg-equg-T20575-Ab-1/ GM-Tg-equg-T20575-Ab-2Anti-Equine CCR8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T20575-Ab-1/ GM-Tg-hg-T20575-Ab-2; GM-Tg-rg-T20575-Ab-1/ GM-Tg-rg-T20575-Ab-2;
GM-Tg-mg-T20575-Ab-1/ GM-Tg-mg-T20575-Ab-2; GM-Tg-cynog-T20575-Ab-1/ GM-Tg-cynog-T20575-Ab-2;
GM-Tg-felg-T20575-Ab-1/ GM-Tg-felg-T20575-Ab-2; GM-Tg-cang-T20575-Ab-1/ GM-Tg-cang-T20575-Ab-2;
GM-Tg-bovg-T20575-Ab-1/ GM-Tg-bovg-T20575-Ab-2; GM-Tg-equg-T20575-Ab-1/ GM-Tg-equg-T20575-Ab-2
Products NameAnti-CCR8 monoclonal antibody
Formatmab
Target NameCCR8
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCR8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CCR8/ CC-CKR-8/ CCR-8 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T20575-Ag-1chemokine (C-C motif) receptor 8 (CCR8) protein
    ORF Viral VectorvGMLP003581human CCR8 Lentivirus particle
    ORF Viral VectorpGMLP003581human CCR8 Lentivirus plasmid
    ORF Viral VectorpGMLPm002781mouse Ccr8 Lentivirus plasmid
    ORF Viral VectorvGMLPm002781mouse Ccr8 Lentivirus particle


    Target information

    Target IDGM-T20575
    Target NameCCR8
    Gene ID1237,12776,301066,693806,485600,101099650,407772,100055409
    Gene Symbol and SynonymsC-C,C-C CKR-8,CC-CKR-8,CCR-8,CCR8,CDw198,CKR-8,CKRL1,CMKBR8,CMKBRL2,CY6,GPRCY6,mCCR8,TER1
    Uniprot AccessionP51685,O97665
    Uniprot Entry NameCCR8_HUMAN,CCR8_MACMU
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000179934
    Target ClassificationGPCR

    The target: CCR8, gene name: CCR8, also named as CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.