Anti-CCL11/ SCYA11 functional antibody

Anti-CCL11/ SCYA11 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CCL11/CCL11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T16888-Ab-1/ GM-Tg-hg-T16888-Ab-2Anti-Human CCL11 monoclonal antibodyHuman
GM-Tg-rg-T16888-Ab-1/ GM-Tg-rg-T16888-Ab-2Anti-Rat CCL11 monoclonal antibodyRat
GM-Tg-mg-T16888-Ab-1/ GM-Tg-mg-T16888-Ab-2Anti-Mouse CCL11 monoclonal antibodyMouse
GM-Tg-cynog-T16888-Ab-1/ GM-Tg-cynog-T16888-Ab-2Anti-Cynomolgus/ Rhesus macaque CCL11 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T16888-Ab-1/ GM-Tg-felg-T16888-Ab-2Anti-Feline CCL11 monoclonal antibodyFeline
GM-Tg-cang-T16888-Ab-1/ GM-Tg-cang-T16888-Ab-2Anti-Canine CCL11 monoclonal antibodyCanine
GM-Tg-bovg-T16888-Ab-1/ GM-Tg-bovg-T16888-Ab-2Anti-Bovine CCL11 monoclonal antibodyBovine
GM-Tg-equg-T16888-Ab-1/ GM-Tg-equg-T16888-Ab-2Anti-Equine CCL11 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T16888-Ab-1/ GM-Tg-hg-T16888-Ab-2; GM-Tg-rg-T16888-Ab-1/ GM-Tg-rg-T16888-Ab-2;
GM-Tg-mg-T16888-Ab-1/ GM-Tg-mg-T16888-Ab-2; GM-Tg-cynog-T16888-Ab-1/ GM-Tg-cynog-T16888-Ab-2;
GM-Tg-felg-T16888-Ab-1/ GM-Tg-felg-T16888-Ab-2; GM-Tg-cang-T16888-Ab-1/ GM-Tg-cang-T16888-Ab-2;
GM-Tg-bovg-T16888-Ab-1/ GM-Tg-bovg-T16888-Ab-2; GM-Tg-equg-T16888-Ab-1/ GM-Tg-equg-T16888-Ab-2
Products NameAnti-CCL11 monoclonal antibody
Formatmab
Target NameCCL11
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCL11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-755Pre-Made Bertilimumab Biosimilar, Whole Mab, Anti-Ccl11 Antibody: Anti-SCYA11 therapeutic antibody
    Target AntigenGM-Tg-g-T16888-Ag-1Recombinant multi-species CCL11/ SCYA11 protein
    CytokineGM-Tg-g-T16888-Ag-1chemokine (C-C motif) ligand 11 (CCL11) protein
    ORF Viral VectorpGMLP000540human CCL11 Lentivirus plasmid
    ORF Viral VectorvGMLP000540human CCL11 Lentivirus particle
    ORF Viral VectorvGMAP000414Human CCL11 Adenovirus particle
    ORF Viral VectorpGMAP000414Human CCL11 Adenovirus plasmid
    ORF Viral VectorpGMLPm000041mouse Ccl11 Lentivirus plasmid
    ORF Viral VectorvGMLPm000041mouse Ccl11 Lentivirus particle


    Target information

    Target IDGM-T16888
    Target NameCCL11
    Gene ID6356,574218
    Gene Symbol and SynonymsCCL11,Eotaxin,SCYA11
    Uniprot AccessionP51671,Q8MIT7
    Uniprot Entry NameCCL11_HUMAN,CCL11_MACMU
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseOvary Cancer
    Gene EnsemblENSG00000172156
    Target ClassificationN/A

    The target: CCL11, gene name: CCL11, also named as SCYA11. This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.