Anti-IL1A/ IL-1A/ IL1 monoclonal antibody

Anti-IL1A/ IL-1A/ IL1 antibody for FACS & in-vivo assay

Target products collectionGo to IL1A/IL1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T16340-Ab-1/ GM-Tg-hg-T16340-Ab-2Anti-Human IL1A monoclonal antibodyHuman
GM-Tg-rg-T16340-Ab-1/ GM-Tg-rg-T16340-Ab-2Anti-Rat IL1A monoclonal antibodyRat
GM-Tg-mg-T16340-Ab-1/ GM-Tg-mg-T16340-Ab-2Anti-Mouse IL1A monoclonal antibodyMouse
GM-Tg-cynog-T16340-Ab-1/ GM-Tg-cynog-T16340-Ab-2Anti-Cynomolgus/ Rhesus macaque IL1A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T16340-Ab-1/ GM-Tg-felg-T16340-Ab-2Anti-Feline IL1A monoclonal antibodyFeline
GM-Tg-cang-T16340-Ab-1/ GM-Tg-cang-T16340-Ab-2Anti-Canine IL1A monoclonal antibodyCanine
GM-Tg-bovg-T16340-Ab-1/ GM-Tg-bovg-T16340-Ab-2Anti-Bovine IL1A monoclonal antibodyBovine
GM-Tg-equg-T16340-Ab-1/ GM-Tg-equg-T16340-Ab-2Anti-Equine IL1A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T16340-Ab-1/ GM-Tg-hg-T16340-Ab-2; GM-Tg-rg-T16340-Ab-1/ GM-Tg-rg-T16340-Ab-2;
GM-Tg-mg-T16340-Ab-1/ GM-Tg-mg-T16340-Ab-2; GM-Tg-cynog-T16340-Ab-1/ GM-Tg-cynog-T16340-Ab-2;
GM-Tg-felg-T16340-Ab-1/ GM-Tg-felg-T16340-Ab-2; GM-Tg-cang-T16340-Ab-1/ GM-Tg-cang-T16340-Ab-2;
GM-Tg-bovg-T16340-Ab-1/ GM-Tg-bovg-T16340-Ab-2; GM-Tg-equg-T16340-Ab-1/ GM-Tg-equg-T16340-Ab-2
Products NameAnti-IL1A monoclonal antibody
Formatmab
Target NameIL1A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL1A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-063Pre-Made Bermekimab biosimilar, Whole mAb, Anti-IL1A Antibody: Anti-IL1/IL-1A/IL1F1/IL1-ALPHA/IL-1 alpha therapeutic antibody
    BiosimilarGMP-Bios-ab-331Pre-Made Lutikizumab biosimilar, Bispecific Dual Variable Domain IG, Anti-IL1A;IL1B Antibody: Anti-IL1/IL-1A/IL1F1/IL1-ALPHA/IL-1 alpha;IL-1/IL1-BETA/IL1F2/IL1beta therapeutic antibody
    Target AntigenProducts DevelopingMulti-species IL1A/ IL-1A/ IL1 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T16340-Ag-1interleukin 1, alpha (IL1A) protein
    ORF Viral VectorpGMAP000157Human IL1A Adenovirus plasmid
    ORF Viral VectorvGMAP000157Human IL1A Adenovirus particle
    ORF Viral VectorpGMLPm000394mouse Il1a Lentivirus plasmid
    ORF Viral VectorvGMLPm000394mouse Il1a Lentivirus particle


    Target information

    Target IDGM-T16340
    Target NameIL1A
    Gene ID3552,16175,24493,700193,403782,493944,281250,100064969
    Gene Symbol and SynonymsIL-1 alpha,IL-1A,IL-1F1,IL1,IL1-ALPHA,IL1A,IL1F1,L1A
    Uniprot AccessionP01583,P16598,P48089,O46612,O46613,P08831,Q28385
    Uniprot Entry NameIL1A_HUMAN,IL1A_MACMU,IL1A_RAT,IL1A_FELCA,IL1A_CANLF,IL1A_BOVIN,IL1A_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseSarcoidosis, ovarian cancer, Urinary bladder urothelial carcinoma
    Gene EnsemblENSG00000115008
    Target ClassificationN/A

    The target: IL1A, gene name: IL1A, also named as IL-1A, IL1, IL1-ALPHA, IL1F1. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.