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Anti-CCL5/ D17S136E/ RANTES functional antibody
Anti-CCL5/ D17S136E/ RANTES functional antibody for cell culture, ELISA & in-vivo assay
Go to CCL5/CCL5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T16263-Ab-1/ GM-Tg-hg-T16263-Ab-2 | Anti-Human CCL5 monoclonal antibody | Human |
| GM-Tg-rg-T16263-Ab-1/ GM-Tg-rg-T16263-Ab-2 | Anti-Rat CCL5 monoclonal antibody | Rat |
| GM-Tg-mg-T16263-Ab-1/ GM-Tg-mg-T16263-Ab-2 | Anti-Mouse CCL5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T16263-Ab-1/ GM-Tg-cynog-T16263-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCL5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T16263-Ab-1/ GM-Tg-felg-T16263-Ab-2 | Anti-Feline CCL5 monoclonal antibody | Feline |
| GM-Tg-cang-T16263-Ab-1/ GM-Tg-cang-T16263-Ab-2 | Anti-Canine CCL5 monoclonal antibody | Canine |
| GM-Tg-bovg-T16263-Ab-1/ GM-Tg-bovg-T16263-Ab-2 | Anti-Bovine CCL5 monoclonal antibody | Bovine |
| GM-Tg-equg-T16263-Ab-1/ GM-Tg-equg-T16263-Ab-2 | Anti-Equine CCL5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T16263-Ab-1/ GM-Tg-hg-T16263-Ab-2; GM-Tg-rg-T16263-Ab-1/ GM-Tg-rg-T16263-Ab-2; GM-Tg-mg-T16263-Ab-1/ GM-Tg-mg-T16263-Ab-2; GM-Tg-cynog-T16263-Ab-1/ GM-Tg-cynog-T16263-Ab-2; GM-Tg-felg-T16263-Ab-1/ GM-Tg-felg-T16263-Ab-2; GM-Tg-cang-T16263-Ab-1/ GM-Tg-cang-T16263-Ab-2; GM-Tg-bovg-T16263-Ab-1/ GM-Tg-bovg-T16263-Ab-2; GM-Tg-equg-T16263-Ab-1/ GM-Tg-equg-T16263-Ab-2 |
| Products Name | Anti-CCL5 monoclonal antibody |
| Format | mab |
| Target Name | CCL5 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCL5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T16263-Ag-1 | Recombinant multi-species CCL5/ D17S136E/ RANTES protein |
| Cytokine | GM-Tg-g-T16263-Ag-1 | chemokine (C-C motif) ligand 5 (CCL5) protein |
| ORF Viral Vector | pGMAP000062 | Human CCL5 Adenovirus plasmid |
| ORF Viral Vector | pGMAP000013 | Human CCL5 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000013 | Human CCL5 Adenovirus particle |
| ORF Viral Vector | vGMAP000062 | Human CCL5 Adenovirus particle |
| ORF Viral Vector | pGMLPm000047 | mouse Ccl5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000047 | mouse Ccl5 Lentivirus particle |
Target information
| Target ID | GM-T16263 |
| Target Name | CCL5 |
| Gene ID | 6352,20304,81780,574178,403522,493689,327712,100033925 |
| Gene Symbol and Synonyms | CCL5,D17S136E,eoCP,MuRantes,RANTES,SCYA5,SIS-delta,SISd,TCP228 |
| Uniprot Accession | P13501,P50231,Q8HYQ1,Q8HYS0,Q8SQ40,O97919,Q8MKD0 |
| Uniprot Entry Name | CCL5_HUMAN,CCL5_MACMU,CCL5_RAT,CCL5_FELCA,CCL5_CANLF,CCL5_BOVIN,CCL5_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Breast Cancer, Type 1 diabetes mellitus, Chronic Kidney Disease |
| Gene Ensembl | ENSG00000271503 |
| Target Classification | N/A |
The target: CCL5, gene name: CCL5, also named as D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP. This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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