Anti-TP53 monoclonal antibody

Pre-made anti-TP53 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to TP53/TP53 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T15739-Ab-1/ GM-Tg-hg-T15739-Ab-2Anti-Human TP53 monoclonal antibodyHuman
GM-Tg-rg-T15739-Ab-1/ GM-Tg-rg-T15739-Ab-2Anti-Rat TP53 monoclonal antibodyRat
GM-Tg-mg-T15739-Ab-1/ GM-Tg-mg-T15739-Ab-2Anti-Mouse TP53 monoclonal antibodyMouse
GM-Tg-cynog-T15739-Ab-1/ GM-Tg-cynog-T15739-Ab-2Anti-Cynomolgus/ Rhesus macaque TP53 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T15739-Ab-1/ GM-Tg-felg-T15739-Ab-2Anti-Feline TP53 monoclonal antibodyFeline
GM-Tg-cang-T15739-Ab-1/ GM-Tg-cang-T15739-Ab-2Anti-Canine TP53 monoclonal antibodyCanine
GM-Tg-bovg-T15739-Ab-1/ GM-Tg-bovg-T15739-Ab-2Anti-Bovine TP53 monoclonal antibodyBovine
GM-Tg-equg-T15739-Ab-1/ GM-Tg-equg-T15739-Ab-2Anti-Equine TP53 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T15739-Ab-1/ GM-Tg-hg-T15739-Ab-2; GM-Tg-rg-T15739-Ab-1/ GM-Tg-rg-T15739-Ab-2;
GM-Tg-mg-T15739-Ab-1/ GM-Tg-mg-T15739-Ab-2; GM-Tg-cynog-T15739-Ab-1/ GM-Tg-cynog-T15739-Ab-2;
GM-Tg-felg-T15739-Ab-1/ GM-Tg-felg-T15739-Ab-2; GM-Tg-cang-T15739-Ab-1/ GM-Tg-cang-T15739-Ab-2;
GM-Tg-bovg-T15739-Ab-1/ GM-Tg-bovg-T15739-Ab-2; GM-Tg-equg-T15739-Ab-1/ GM-Tg-equg-T15739-Ab-2
Products NameAnti-TP53 monoclonal antibody
Formatmab
Target NameTP53
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-TP53 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T15739-Ag-1Recombinant multi-species P53/ TP53/ BCC7 protein
    ORF Viral VectorvGMAAV000014human TP53 AAV particle
    ORF Viral VectorpGMAP000334Human TP53 Adenovirus plasmid
    ORF Viral VectorpGMAD000013human TP53 Adenovirus plasmid
    ORF Viral VectorvGMAD000013human TP53 Adenovirus particle
    ORF Viral VectorpGMAAV000014human TP53 AAV plasmid
    ORF Viral VectorvGMAP000334Human TP53 Adenovirus particle
    ORF Viral VectorpGMAD000347rat Tp53 Adenovirus plasmid
    ORF Viral VectorvGMAD000347rat Tp53 Adenovirus particle
    ORF Viral VectorpGMAD000539house mouse Trp53 Adenovirus plasmid
    ORF Viral VectorvGMAD000539house mouse Trp53 Adenovirus particle


    Target information

    Target IDGM-T15739
    Target NameTP53
    Gene ID7157,22059,24842,716170,403869,493847,281542,100062044
    Gene Symbol and Synonymsbbl,BCC7,bfy,bhy,BMFS5,LFS1,p44,P53,TP53,TRP53
    Uniprot AccessionP04637,P10361,P56424,Q29537,P41685,P67939,P79892
    Uniprot Entry NameP53_HUMAN,P53_MACMU,P53_RAT,P53_FELCA,P53_CANLF,P53_BOVIN,P53_HORSE
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseLung Cancer, lung cancers, Lung cancer, Lung, Colon cancer, Bone metastasis, Liver neoplasms, Lung neoplasms
    Gene EnsemblENSG00000141510
    Target ClassificationN/A

    The target: TP53, gene name: TP53, also named as BCC7, LFS1, P53, TRP53. This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.