Anti-TGFB2/ G-TSF/ LDS4 functional antibody

Anti-TGFB2/ G-TSF/ LDS4 functional antibody for cell culture, ELISA & in-vivo assay

Go to TGFB2/TGFB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

MSDSCOADatasheet
Inquiry

Product information

Size： 1mg | 10mg | 100mg

Product Description

Reference

Data / case study

Click to get more Data / Case study about the product.

Associated products

Target information

The target: TGFB2, gene name: TGFB2, also named as G-TSF, LDS4, TGF-beta2. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].

About Gmab