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Anti-IL12A/ CLMF/ IL-12A functional antibody
Anti-IL12A/ CLMF/ IL-12A functional antibody for cell culture, ELISA & in-vivo assay
Go to IL12A/IL12A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T13251-Ab-1/ GM-Tg-hg-T13251-Ab-2 | Anti-Human IL12A monoclonal antibody | Human |
| GM-Tg-rg-T13251-Ab-1/ GM-Tg-rg-T13251-Ab-2 | Anti-Rat IL12A monoclonal antibody | Rat |
| GM-Tg-mg-T13251-Ab-1/ GM-Tg-mg-T13251-Ab-2 | Anti-Mouse IL12A monoclonal antibody | Mouse |
| GM-Tg-cynog-T13251-Ab-1/ GM-Tg-cynog-T13251-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL12A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T13251-Ab-1/ GM-Tg-felg-T13251-Ab-2 | Anti-Feline IL12A monoclonal antibody | Feline |
| GM-Tg-cang-T13251-Ab-1/ GM-Tg-cang-T13251-Ab-2 | Anti-Canine IL12A monoclonal antibody | Canine |
| GM-Tg-bovg-T13251-Ab-1/ GM-Tg-bovg-T13251-Ab-2 | Anti-Bovine IL12A monoclonal antibody | Bovine |
| GM-Tg-equg-T13251-Ab-1/ GM-Tg-equg-T13251-Ab-2 | Anti-Equine IL12A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T13251-Ab-1/ GM-Tg-hg-T13251-Ab-2; GM-Tg-rg-T13251-Ab-1/ GM-Tg-rg-T13251-Ab-2; GM-Tg-mg-T13251-Ab-1/ GM-Tg-mg-T13251-Ab-2; GM-Tg-cynog-T13251-Ab-1/ GM-Tg-cynog-T13251-Ab-2; GM-Tg-felg-T13251-Ab-1/ GM-Tg-felg-T13251-Ab-2; GM-Tg-cang-T13251-Ab-1/ GM-Tg-cang-T13251-Ab-2; GM-Tg-bovg-T13251-Ab-1/ GM-Tg-bovg-T13251-Ab-2; GM-Tg-equg-T13251-Ab-1/ GM-Tg-equg-T13251-Ab-2 |
| Products Name | Anti-IL12A monoclonal antibody |
| Format | mab |
| Target Name | IL12A |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL12A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T13251-Ag-1 | Recombinant multi-species IL12A/ CLMF/ IL-12A protein |
| Cytokine | GM-Tg-g-T13251-Ag-1 | IL-12 p70 (IL12A) protein |
| ORF Viral Vector | pGMLV000443 | human IL12A Lentivirus plasmid |
| ORF Viral Vector | vGMLV000443 | human IL12A Lentivirus particle |
Target information
| Target ID | GM-T13251 |
| Target Name | IL12A |
| Gene ID | 3592,16159,84405,703205,403977,493741,281856,100034215 |
| Gene Symbol and Synonyms | CLMF,CLMF p35,Il-12 p35,IL-12A,IL-12p35,IL12A,IL12p35,Ll12a,NFSK,NKSF1,P35 |
| Uniprot Accession | P29459,Q9R103,P48091,Q28267,O02743,P54349,Q9XSQ6 |
| Uniprot Entry Name | IL12A_HUMAN,IL12A_MACMU,IL12A_RAT,IL12A_FELCA,IL12A_CANLF,IL12A_BOVIN,IL12A_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | malignant glioma |
| Gene Ensembl | ENSG00000168811 |
| Target Classification | N/A |
The target: IL12A, gene name: IL12A, also named as CLMF, IL-12A, NFSK, NKSF1, P35. This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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