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Anti-IL31/ IL-31 functional antibody
Anti-IL31/ IL-31 functional antibody for cell culture, ELISA & in-vivo assay
Go to IL31/IL31 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T11701-Ab-1/ GM-Tg-hg-T11701-Ab-2 | Anti-Human IL31 monoclonal antibody | Human |
| GM-Tg-rg-T11701-Ab-1/ GM-Tg-rg-T11701-Ab-2 | Anti-Rat IL31 monoclonal antibody | Rat |
| GM-Tg-mg-T11701-Ab-1/ GM-Tg-mg-T11701-Ab-2 | Anti-Mouse IL31 monoclonal antibody | Mouse |
| GM-Tg-cynog-T11701-Ab-1/ GM-Tg-cynog-T11701-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL31 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T11701-Ab-1/ GM-Tg-felg-T11701-Ab-2 | Anti-Feline IL31 monoclonal antibody | Feline |
| GM-Tg-cang-T11701-Ab-1/ GM-Tg-cang-T11701-Ab-2 | Anti-Canine IL31 monoclonal antibody | Canine |
| GM-Tg-bovg-T11701-Ab-1/ GM-Tg-bovg-T11701-Ab-2 | Anti-Bovine IL31 monoclonal antibody | Bovine |
| GM-Tg-equg-T11701-Ab-1/ GM-Tg-equg-T11701-Ab-2 | Anti-Equine IL31 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T11701-Ab-1/ GM-Tg-hg-T11701-Ab-2; GM-Tg-rg-T11701-Ab-1/ GM-Tg-rg-T11701-Ab-2; GM-Tg-mg-T11701-Ab-1/ GM-Tg-mg-T11701-Ab-2; GM-Tg-cynog-T11701-Ab-1/ GM-Tg-cynog-T11701-Ab-2; GM-Tg-felg-T11701-Ab-1/ GM-Tg-felg-T11701-Ab-2; GM-Tg-cang-T11701-Ab-1/ GM-Tg-cang-T11701-Ab-2; GM-Tg-bovg-T11701-Ab-1/ GM-Tg-bovg-T11701-Ab-2; GM-Tg-equg-T11701-Ab-1/ GM-Tg-equg-T11701-Ab-2 |
| Products Name | Anti-IL31 monoclonal antibody |
| Format | mab |
| Target Name | IL31 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL31 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-319 | Pre-Made Lokivetmab biosimilar, Canine Whole Mab: Anti-IL31 therapeutic antibody |
| Biosimilar | GMP-Bios-ab-155 | Pre-Made Dovanvetmab biosimilar, Feline Whole Mab: Anti-IL31 (Feline) therapeutic antibody |
| Target Antigen | GM-Tg-g-T11701-Ag-1 | Recombinant multi-species IL31/ IL-31 protein |
| Cytokine | GM-Tg-g-T11701-Ag-1 | interleukin 31 (Il31) protein |
| ORF Viral Vector | pGMLP004789 | human IL31 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004789 | human IL31 Lentivirus particle |
| ORF Viral Vector | pGMLPm000300 | mouse Il31 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000300 | mouse Il31 Lentivirus particle |
Target information
| Target ID | GM-T11701 |
| Target Name | IL31 |
| Gene ID | 386653,76399,690028,701655,100302725,105261056,102149194 |
| Gene Symbol and Synonyms | 1700013B14Rik,AABR07036324.1,IL-31,IL31 |
| Uniprot Accession | Q6EBC2 |
| Uniprot Entry Name | IL31_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000204671 |
| Target Classification | N/A |
The target: IL31, gene name: IL31, also named as IL-31. IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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