Anti-ACKR3/ CMKOR1/ CXC-R7 monoclonal antibody

Anti-ACKR3/ CMKOR1/ CXC-R7 antibody for FACS & in-vivo assay

Target products collectionGo to ACKR3/ACKR3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T10491-Ab-1/ GM-Tg-hg-T10491-Ab-2Anti-Human ACKR3 monoclonal antibodyHuman
GM-Tg-rg-T10491-Ab-1/ GM-Tg-rg-T10491-Ab-2Anti-Rat ACKR3 monoclonal antibodyRat
GM-Tg-mg-T10491-Ab-1/ GM-Tg-mg-T10491-Ab-2Anti-Mouse ACKR3 monoclonal antibodyMouse
GM-Tg-cynog-T10491-Ab-1/ GM-Tg-cynog-T10491-Ab-2Anti-Cynomolgus/ Rhesus macaque ACKR3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T10491-Ab-1/ GM-Tg-felg-T10491-Ab-2Anti-Feline ACKR3 monoclonal antibodyFeline
GM-Tg-cang-T10491-Ab-1/ GM-Tg-cang-T10491-Ab-2Anti-Canine ACKR3 monoclonal antibodyCanine
GM-Tg-bovg-T10491-Ab-1/ GM-Tg-bovg-T10491-Ab-2Anti-Bovine ACKR3 monoclonal antibodyBovine
GM-Tg-equg-T10491-Ab-1/ GM-Tg-equg-T10491-Ab-2Anti-Equine ACKR3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T10491-Ab-1/ GM-Tg-hg-T10491-Ab-2; GM-Tg-rg-T10491-Ab-1/ GM-Tg-rg-T10491-Ab-2;
GM-Tg-mg-T10491-Ab-1/ GM-Tg-mg-T10491-Ab-2; GM-Tg-cynog-T10491-Ab-1/ GM-Tg-cynog-T10491-Ab-2;
GM-Tg-felg-T10491-Ab-1/ GM-Tg-felg-T10491-Ab-2; GM-Tg-cang-T10491-Ab-1/ GM-Tg-cang-T10491-Ab-2;
GM-Tg-bovg-T10491-Ab-1/ GM-Tg-bovg-T10491-Ab-2; GM-Tg-equg-T10491-Ab-1/ GM-Tg-equg-T10491-Ab-2
Products NameAnti-ACKR3 monoclonal antibody
Formatmab
Target NameACKR3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ACKR3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ACKR3/ CMKOR1/ CXC-R7 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T10491-Ag-1chemokine (C-X-C motif) receptor 7 (CXCR7) protein
    ORF Viral VectorpGMLV000082human ACKR3 Lentivirus plasmid
    ORF Viral VectorvGMAP000125Human CXCR7 Adenovirus particle
    ORF Viral VectorpGMLP003139human ACKR3 Lentivirus plasmid
    ORF Viral VectorvGMLP003139human ACKR3 Lentivirus particle
    ORF Viral VectorpGMAP000125Human CXCR7 Adenovirus plasmid
    ORF Viral VectorpGMLV000566human ACKR3 Lentivirus plasmid
    ORF Viral VectorpGMAP000127Human CXCR7 Adenovirus plasmid
    ORF Viral VectorvGMLV000082human ACKR3 Lentivirus particle
    ORF Viral VectorvGMAP000127Human CXCR7 Adenovirus particle
    ORF Viral VectorvGMLV000566human ACKR3 Lentivirus particle
    ORF Viral VectorpGMLV000349mouse Ackr3 Lentivirus plasmid
    ORF Viral VectorpGMAD000104mouse Ackr3 Adenovirus plasmid
    ORF Viral VectorpGMAAV000021mouse Ackr3 AAV plasmid
    ORF Viral VectorvGMLV000349mouse Ackr3 Lentivirus particle
    ORF Viral VectorvGMAD000104mouse Ackr3 Adenovirus particle
    ORF Viral VectorvGMAAV000021mouse Ackr3 AAV particle


    Target information

    Target IDGM-T10491
    Target NameACKR3
    Gene ID57007,12778,84348,694428,403964,101080817,509585,100057501
    Gene Symbol and SynonymsACKR3,CMKOR1,CXC-R7,CXCR-7,CXCR7,GPR159,RDC-1,RDC1
    Uniprot AccessionP25106,O89039,P11613
    Uniprot Entry NameACKR3_HUMAN,ACKR3_RAT,ACKR3_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000144476
    Target ClassificationCheckpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA)

    The target: ACKR3, gene name: ACKR3, also named as CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1. This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.