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Anti-IL10/ CSIF/ GVHDS functional antibody
Anti-IL10/ CSIF/ GVHDS functional antibody for cell culture, ELISA & in-vivo assay
Go to IL10/IL10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T09092-Ab-1/ GM-Tg-hg-T09092-Ab-2 | Anti-Human IL10 monoclonal antibody | Human |
| GM-Tg-rg-T09092-Ab-1/ GM-Tg-rg-T09092-Ab-2 | Anti-Rat IL10 monoclonal antibody | Rat |
| GM-Tg-mg-T09092-Ab-1/ GM-Tg-mg-T09092-Ab-2 | Anti-Mouse IL10 monoclonal antibody | Mouse |
| GM-Tg-cynog-T09092-Ab-1/ GM-Tg-cynog-T09092-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL10 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T09092-Ab-1/ GM-Tg-felg-T09092-Ab-2 | Anti-Feline IL10 monoclonal antibody | Feline |
| GM-Tg-cang-T09092-Ab-1/ GM-Tg-cang-T09092-Ab-2 | Anti-Canine IL10 monoclonal antibody | Canine |
| GM-Tg-bovg-T09092-Ab-1/ GM-Tg-bovg-T09092-Ab-2 | Anti-Bovine IL10 monoclonal antibody | Bovine |
| GM-Tg-equg-T09092-Ab-1/ GM-Tg-equg-T09092-Ab-2 | Anti-Equine IL10 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T09092-Ab-1/ GM-Tg-hg-T09092-Ab-2; GM-Tg-rg-T09092-Ab-1/ GM-Tg-rg-T09092-Ab-2; GM-Tg-mg-T09092-Ab-1/ GM-Tg-mg-T09092-Ab-2; GM-Tg-cynog-T09092-Ab-1/ GM-Tg-cynog-T09092-Ab-2; GM-Tg-felg-T09092-Ab-1/ GM-Tg-felg-T09092-Ab-2; GM-Tg-cang-T09092-Ab-1/ GM-Tg-cang-T09092-Ab-2; GM-Tg-bovg-T09092-Ab-1/ GM-Tg-bovg-T09092-Ab-2; GM-Tg-equg-T09092-Ab-1/ GM-Tg-equg-T09092-Ab-2 |
| Products Name | Anti-IL10 monoclonal antibody |
| Format | mab |
| Target Name | IL10 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T09092-Ag-1 | Recombinant multi-species IL10/ CSIF/ GVHDS protein |
| Cytokine | GM-Tg-g-T09092-Ag-1 | interleukin 10 (IL10) protein |
| ORF Viral Vector | vGMAD000014 | human IL10 Adenovirus particle |
| ORF Viral Vector | vGMAP000484 | Human IL10 Adenovirus particle |
| ORF Viral Vector | vGMAP000590 | Human IL10 Adenovirus particle |
| ORF Viral Vector | pGMAP000484 | Human IL10 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000014 | human IL10 Adenovirus plasmid |
| ORF Viral Vector | pGMAP000590 | Human IL10 Adenovirus plasmid |
| ORF Viral Vector | pGMLV000148 | mouse Il10 Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000052 | mouse Il10 AAV plasmid |
| ORF Viral Vector | pGMAAV000053 | mouse Il10 AAV plasmid |
| ORF Viral Vector | pGMLPm004019 | mouse Il10 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000148 | mouse Il10 Lentivirus particle |
| ORF Viral Vector | vGMAAV000052 | mouse Il10 AAV particle |
| ORF Viral Vector | vGMAAV000053 | mouse Il10 AAV particle |
| ORF Viral Vector | vGMLPm004019 | mouse Il10 Lentivirus particle |
Target information
| Target ID | GM-T09092 |
| Target Name | IL10 |
| Gene ID | 3586,16153,25325,694931,403628,493683,281246,100034187 |
| Gene Symbol and Synonyms | CSIF,GVHDS,If2a,IL-10,IL10,IL10A,IL10X,TGIF |
| Uniprot Accession | P22301,P29456,P51496,P48411,P55029,P43480,Q28374 |
| Uniprot Entry Name | IL10_HUMAN,IL10_MACMU,IL10_RAT,IL10_FELCA,IL10_CANLF,IL10_BOVIN,IL10_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Ovary Cancer, metastases, asthma, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000136634 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IL10, gene name: IL10, also named as CSIF, GVHDS, IL-10A, TGIF, IL10. The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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