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Anti-PDGFA/ PDGF-A/ PDGF1 functional antibody
Anti-PDGFA/ PDGF-A/ PDGF1 functional antibody for cell culture, ELISA & in-vivo assay
Go to PDGFA/PDGFA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T06869-Ab-1/ GM-Tg-hg-T06869-Ab-2 | Anti-Human PDGFA monoclonal antibody | Human |
| GM-Tg-rg-T06869-Ab-1/ GM-Tg-rg-T06869-Ab-2 | Anti-Rat PDGFA monoclonal antibody | Rat |
| GM-Tg-mg-T06869-Ab-1/ GM-Tg-mg-T06869-Ab-2 | Anti-Mouse PDGFA monoclonal antibody | Mouse |
| GM-Tg-cynog-T06869-Ab-1/ GM-Tg-cynog-T06869-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PDGFA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T06869-Ab-1/ GM-Tg-felg-T06869-Ab-2 | Anti-Feline PDGFA monoclonal antibody | Feline |
| GM-Tg-cang-T06869-Ab-1/ GM-Tg-cang-T06869-Ab-2 | Anti-Canine PDGFA monoclonal antibody | Canine |
| GM-Tg-bovg-T06869-Ab-1/ GM-Tg-bovg-T06869-Ab-2 | Anti-Bovine PDGFA monoclonal antibody | Bovine |
| GM-Tg-equg-T06869-Ab-1/ GM-Tg-equg-T06869-Ab-2 | Anti-Equine PDGFA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T06869-Ab-1/ GM-Tg-hg-T06869-Ab-2; GM-Tg-rg-T06869-Ab-1/ GM-Tg-rg-T06869-Ab-2; GM-Tg-mg-T06869-Ab-1/ GM-Tg-mg-T06869-Ab-2; GM-Tg-cynog-T06869-Ab-1/ GM-Tg-cynog-T06869-Ab-2; GM-Tg-felg-T06869-Ab-1/ GM-Tg-felg-T06869-Ab-2; GM-Tg-cang-T06869-Ab-1/ GM-Tg-cang-T06869-Ab-2; GM-Tg-bovg-T06869-Ab-1/ GM-Tg-bovg-T06869-Ab-2; GM-Tg-equg-T06869-Ab-1/ GM-Tg-equg-T06869-Ab-2 |
| Products Name | Anti-PDGFA monoclonal antibody |
| Format | mab |
| Target Name | PDGFA |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PDGFA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T06869-Ag-1 | Recombinant multi-species PDGFA/ PDGF-A/ PDGF1 protein |
| Cytokine | GM-Tg-g-T06869-Ag-1 | platelet-derived growth factor alpha polypeptide (PDGFA) protein |
| ORF Viral Vector | vGMAD000143 | human PDGFA Adenovirus particle |
| ORF Viral Vector | pGMAD000143 | human PDGFA Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000269 | mouse Pdgfa Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000269 | mouse Pdgfa Lentivirus particle |
Target information
| Target ID | GM-T06869 |
| Target Name | PDGFA |
| Gene ID | 5154,18590,25266,707725,491597,101087287,505908,100055086 |
| Gene Symbol and Synonyms | PDGF-1,PDGF-A,PDGF1,PDGFA,PDGFACP |
| Uniprot Accession | P04085,P28576,Q2KJ15 |
| Uniprot Entry Name | PDGFA_HUMAN,PDGFA_RAT,PDGFA_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Breast Cancer, Type 1 diabetes mellitus |
| Gene Ensembl | ENSG00000197461 |
| Target Classification | N/A |
The target: PDGFA, gene name: PDGFA, also named as PDGF-A, PDGF1. This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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