Anti-ANXA2/ ANX2/ ANX2L4 monoclonal antibody

Anti-ANXA2/ ANX2/ ANX2L4 antibody for FACS & in-vivo assay

Target products collectionGo to ANXA2/ANXA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T04386-Ab-1/ GM-Tg-hg-T04386-Ab-2Anti-Human ANXA2 monoclonal antibodyHuman
GM-Tg-rg-T04386-Ab-1/ GM-Tg-rg-T04386-Ab-2Anti-Rat ANXA2 monoclonal antibodyRat
GM-Tg-mg-T04386-Ab-1/ GM-Tg-mg-T04386-Ab-2Anti-Mouse ANXA2 monoclonal antibodyMouse
GM-Tg-cynog-T04386-Ab-1/ GM-Tg-cynog-T04386-Ab-2Anti-Cynomolgus/ Rhesus macaque ANXA2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T04386-Ab-1/ GM-Tg-felg-T04386-Ab-2Anti-Feline ANXA2 monoclonal antibodyFeline
GM-Tg-cang-T04386-Ab-1/ GM-Tg-cang-T04386-Ab-2Anti-Canine ANXA2 monoclonal antibodyCanine
GM-Tg-bovg-T04386-Ab-1/ GM-Tg-bovg-T04386-Ab-2Anti-Bovine ANXA2 monoclonal antibodyBovine
GM-Tg-equg-T04386-Ab-1/ GM-Tg-equg-T04386-Ab-2Anti-Equine ANXA2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T04386-Ab-1/ GM-Tg-hg-T04386-Ab-2; GM-Tg-rg-T04386-Ab-1/ GM-Tg-rg-T04386-Ab-2;
GM-Tg-mg-T04386-Ab-1/ GM-Tg-mg-T04386-Ab-2; GM-Tg-cynog-T04386-Ab-1/ GM-Tg-cynog-T04386-Ab-2;
GM-Tg-felg-T04386-Ab-1/ GM-Tg-felg-T04386-Ab-2; GM-Tg-cang-T04386-Ab-1/ GM-Tg-cang-T04386-Ab-2;
GM-Tg-bovg-T04386-Ab-1/ GM-Tg-bovg-T04386-Ab-2; GM-Tg-equg-T04386-Ab-1/ GM-Tg-equg-T04386-Ab-2
Products NameAnti-ANXA2 monoclonal antibody
Formatmab
Target NameANXA2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ANXA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ANXA2/ ANX2/ ANX2L4 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000652human ANXA2 Lentivirus particle
    ORF Viral VectorpGMAP000385Human ANXA2 Adenovirus plasmid
    ORF Viral VectorpGMLP004063human ANXA2 Lentivirus plasmid
    ORF Viral VectorvGMLP004100human ANXA2 Lentivirus particle
    ORF Viral VectorpGMLV000652human ANXA2 Lentivirus plasmid
    ORF Viral VectorpGMLP004100human ANXA2 Lentivirus plasmid
    ORF Viral VectorvGMLP004063human ANXA2 Lentivirus particle
    ORF Viral VectorvGMAP000385Human ANXA2 Adenovirus particle
    ORF Viral VectorpGMLPm002777mouse Anxa2 Lentivirus plasmid
    ORF Viral VectorvGMLPm002777mouse Anxa2 Lentivirus particle


    Target information

    Target IDGM-T04386
    Target NameANXA2
    Gene ID302,12306,56611,706240,403435,101093022,282689,100054320
    Gene Symbol and SynonymsAnnexin-2,ANX2,ANX2L4,ANXA2,CAL1H,HEL-S-270,LIP2,LPC2,LPC2D,P36,PAP-IV
    Uniprot AccessionP07355,Q07936,Q6TEQ7,P04272
    Uniprot Entry NameANXA2_HUMAN,ANXA2_RAT,ANXA2_CANLF,ANXA2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseOvary Cancer
    Gene EnsemblENSG00000182718
    Target ClassificationN/A

    The target: ANXA2, gene name: ANXA2, also named as ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.