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Anti-OSTP/ SPP1/ BNSP functional antibody
Anti-OSTP/ SPP1/ BNSP functional antibody for cell culture, ELISA & in-vivo assay
Go to SPP1/SPP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T00032-Ab-1/ GM-Tg-hg-T00032-Ab-2 | Anti-Human SPP1 monoclonal antibody | Human |
| GM-Tg-rg-T00032-Ab-1/ GM-Tg-rg-T00032-Ab-2 | Anti-Rat SPP1 monoclonal antibody | Rat |
| GM-Tg-mg-T00032-Ab-1/ GM-Tg-mg-T00032-Ab-2 | Anti-Mouse SPP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T00032-Ab-1/ GM-Tg-cynog-T00032-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T00032-Ab-1/ GM-Tg-felg-T00032-Ab-2 | Anti-Feline SPP1 monoclonal antibody | Feline |
| GM-Tg-cang-T00032-Ab-1/ GM-Tg-cang-T00032-Ab-2 | Anti-Canine SPP1 monoclonal antibody | Canine |
| GM-Tg-bovg-T00032-Ab-1/ GM-Tg-bovg-T00032-Ab-2 | Anti-Bovine SPP1 monoclonal antibody | Bovine |
| GM-Tg-equg-T00032-Ab-1/ GM-Tg-equg-T00032-Ab-2 | Anti-Equine SPP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T00032-Ab-1/ GM-Tg-hg-T00032-Ab-2; GM-Tg-rg-T00032-Ab-1/ GM-Tg-rg-T00032-Ab-2; GM-Tg-mg-T00032-Ab-1/ GM-Tg-mg-T00032-Ab-2; GM-Tg-cynog-T00032-Ab-1/ GM-Tg-cynog-T00032-Ab-2; GM-Tg-felg-T00032-Ab-1/ GM-Tg-felg-T00032-Ab-2; GM-Tg-cang-T00032-Ab-1/ GM-Tg-cang-T00032-Ab-2; GM-Tg-bovg-T00032-Ab-1/ GM-Tg-bovg-T00032-Ab-2; GM-Tg-equg-T00032-Ab-1/ GM-Tg-equg-T00032-Ab-2 |
| Products Name | Anti-SPP1 monoclonal antibody |
| Format | mab |
| Target Name | SPP1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SPP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T00032-Ag-1 | Recombinant multi-species OSTP/ SPP1/ BNSP protein |
| ORF Viral Vector | vGMAP000451 | Human SPP1 Adenovirus particle |
| ORF Viral Vector | vGMAD000037 | human SPP1 Adenovirus particle |
| ORF Viral Vector | vGMLV000419 | human SPP1 Lentivirus particle |
| ORF Viral Vector | pGMAP000451 | Human SPP1 Adenovirus plasmid |
| ORF Viral Vector | pGMLV000419 | human SPP1 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000016 | human SPP1 Adenovirus particle |
| ORF Viral Vector | pGMAD000037 | human SPP1 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000016 | human SPP1 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000326 | mouse Spp1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000326 | mouse Spp1 Lentivirus particle |
Target information
| Target ID | GM-T00032 |
| Target Name | SPP1 |
| Gene ID | 6696,20750,25353,704930,478471,101094264,281499,100053029 |
| Gene Symbol and Synonyms | 2AR,Apl-1,BNSP,Bsp,BSPI,Eta,ETA-1,OP,OPN,Opnl,OSP,OST,Ric,Spp-1,SPP1 |
| Uniprot Accession | P10451,P08721,P31096 |
| Uniprot Entry Name | OSTP_HUMAN,OSTP_RAT,OSTP_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Ovarian cancer, Acute kidney failure, Asphyxia neonatorum, Calculus of kidney, Congenital occlusion of ureteropelvic junction, Contact with and (suspected) exposure to uranium, Dent disease, Hepatic fibrosis, Malignant neoplasm of bladder, Pregnant state, Sepsis |
| Gene Ensembl | ENSG00000118785 |
| Target Classification | N/A |
The target: SPP1, gene name: SPP1, also named as BNSP, BSPI, ETA-1, OPN. The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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