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Anti-7B2/ SCG5/ P7B2 functional antibody
Anti-7B2/ SCG5/ P7B2 functional antibody for cell culture, ELISA & in-vivo assay
Go to SCG5/SCG5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1262-Ab-1/ GM-Tg-hg-SE1262-Ab-2 | Anti-Human SCG5 monoclonal antibody | Human |
| GM-Tg-rg-SE1262-Ab-1/ GM-Tg-rg-SE1262-Ab-2 | Anti-Rat SCG5 monoclonal antibody | Rat |
| GM-Tg-mg-SE1262-Ab-1/ GM-Tg-mg-SE1262-Ab-2 | Anti-Mouse SCG5 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1262-Ab-1/ GM-Tg-cynog-SE1262-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SCG5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1262-Ab-1/ GM-Tg-felg-SE1262-Ab-2 | Anti-Feline SCG5 monoclonal antibody | Feline |
| GM-Tg-cang-SE1262-Ab-1/ GM-Tg-cang-SE1262-Ab-2 | Anti-Canine SCG5 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1262-Ab-1/ GM-Tg-bovg-SE1262-Ab-2 | Anti-Bovine SCG5 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1262-Ab-1/ GM-Tg-equg-SE1262-Ab-2 | Anti-Equine SCG5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1262-Ab-1/ GM-Tg-hg-SE1262-Ab-2; GM-Tg-rg-SE1262-Ab-1/ GM-Tg-rg-SE1262-Ab-2; GM-Tg-mg-SE1262-Ab-1/ GM-Tg-mg-SE1262-Ab-2; GM-Tg-cynog-SE1262-Ab-1/ GM-Tg-cynog-SE1262-Ab-2; GM-Tg-felg-SE1262-Ab-1/ GM-Tg-felg-SE1262-Ab-2; GM-Tg-cang-SE1262-Ab-1/ GM-Tg-cang-SE1262-Ab-2; GM-Tg-bovg-SE1262-Ab-1/ GM-Tg-bovg-SE1262-Ab-2; GM-Tg-equg-SE1262-Ab-1/ GM-Tg-equg-SE1262-Ab-2 |
| Products Name | Anti-SCG5 monoclonal antibody |
| Format | mab |
| Target Name | SCG5 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SCG5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1262-Ag-1 | Recombinant multi-species 7B2/ SCG5/ P7B2 protein |
| ORF Viral Vector | pGMLP001208 | human SCG5 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001208 | human SCG5 Lentivirus particle |
| ORF Viral Vector | pGMLPm002410 | mouse Scg5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002410 | mouse Scg5 Lentivirus particle |
Target information
| Target ID | GM-SE1262 |
| Target Name | SCG5 |
| Gene ID | 6447,20394,25719,694088,508224,100071769 |
| Gene Symbol and Synonyms | 7B2,P7B2,SCG5,Sgne-1,SGNE1,SgV |
| Uniprot Accession | P05408,P27682 |
| Uniprot Entry Name | 7B2_HUMAN,7B2_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000166922 |
| Target Classification | N/A |
The target: SCG5, gene name: SCG5, also named as 7B2, P7B2, SGNE1, SgV. This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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