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Anti-RETN/ ADSF/ FIZZ31 functional antibody
Anti-RETN/ ADSF/ FIZZ31 functional antibody for cell culture, ELISA & in-vivo assay
Go to RETN/RETN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1239-Ab-1/ GM-Tg-hg-SE1239-Ab-2 | Anti-Human RETN monoclonal antibody | Human |
| GM-Tg-rg-SE1239-Ab-1/ GM-Tg-rg-SE1239-Ab-2 | Anti-Rat RETN monoclonal antibody | Rat |
| GM-Tg-mg-SE1239-Ab-1/ GM-Tg-mg-SE1239-Ab-2 | Anti-Mouse RETN monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1239-Ab-1/ GM-Tg-cynog-SE1239-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RETN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1239-Ab-1/ GM-Tg-felg-SE1239-Ab-2 | Anti-Feline RETN monoclonal antibody | Feline |
| GM-Tg-cang-SE1239-Ab-1/ GM-Tg-cang-SE1239-Ab-2 | Anti-Canine RETN monoclonal antibody | Canine |
| GM-Tg-bovg-SE1239-Ab-1/ GM-Tg-bovg-SE1239-Ab-2 | Anti-Bovine RETN monoclonal antibody | Bovine |
| GM-Tg-equg-SE1239-Ab-1/ GM-Tg-equg-SE1239-Ab-2 | Anti-Equine RETN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1239-Ab-1/ GM-Tg-hg-SE1239-Ab-2; GM-Tg-rg-SE1239-Ab-1/ GM-Tg-rg-SE1239-Ab-2; GM-Tg-mg-SE1239-Ab-1/ GM-Tg-mg-SE1239-Ab-2; GM-Tg-cynog-SE1239-Ab-1/ GM-Tg-cynog-SE1239-Ab-2; GM-Tg-felg-SE1239-Ab-1/ GM-Tg-felg-SE1239-Ab-2; GM-Tg-cang-SE1239-Ab-1/ GM-Tg-cang-SE1239-Ab-2; GM-Tg-bovg-SE1239-Ab-1/ GM-Tg-bovg-SE1239-Ab-2; GM-Tg-equg-SE1239-Ab-1/ GM-Tg-equg-SE1239-Ab-2 |
| Products Name | Anti-RETN monoclonal antibody |
| Format | mab |
| Target Name | RETN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RETN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1239-Ag-1 | Recombinant multi-species RETN/ ADSF/ FIZZ31 protein |
| Cytokine | GM-Tg-g-SE1239-Ag-1 | resistin (RETN) protein |
| ORF Viral Vector | vGMLP001996 | human RETN Lentivirus particle |
| ORF Viral Vector | pGMLP001996 | human RETN Lentivirus plasmid |
| ORF Viral Vector | vGMAP000284 | Human RETN Adenovirus particle |
| ORF Viral Vector | pGMAP000284 | Human RETN Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000171 | mouse Retn Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000171 | mouse Retn Lentivirus particle |
Target information
| Target ID | GM-SE1239 |
| Target Name | RETN |
| Gene ID | 56729,57264,246250,708781,611540,100142685,369020,100060741 |
| Gene Symbol and Synonyms | ADSF,FIZZ3,RENT,RETN,RETN1,RSTN,XCP1,Xcp4 |
| Uniprot Accession | Q9HD89,Q762I5 |
| Uniprot Entry Name | RETN_HUMAN,RETN_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Sepsis, Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000104918 |
| Target Classification | N/A |
The target: RETN, gene name: RETN, also named as ADSF, FIZZ31, RSTN, XCP1, RETN. This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. The encoded protein also has an antimicrobial role in skin, displaying antibacterial activity against both Gram positive and Gram negative bacteria. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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