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Anti-MGP/ GIG36/ MGLAP functional antibody
Anti-MGP/ GIG36/ MGLAP functional antibody for cell culture, ELISA & in-vivo assay
Go to MGP/MGP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1099-Ab-1/ GM-Tg-hg-SE1099-Ab-2 | Anti-Human MGP monoclonal antibody | Human |
| GM-Tg-rg-SE1099-Ab-1/ GM-Tg-rg-SE1099-Ab-2 | Anti-Rat MGP monoclonal antibody | Rat |
| GM-Tg-mg-SE1099-Ab-1/ GM-Tg-mg-SE1099-Ab-2 | Anti-Mouse MGP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1099-Ab-1/ GM-Tg-cynog-SE1099-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MGP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1099-Ab-1/ GM-Tg-felg-SE1099-Ab-2 | Anti-Feline MGP monoclonal antibody | Feline |
| GM-Tg-cang-SE1099-Ab-1/ GM-Tg-cang-SE1099-Ab-2 | Anti-Canine MGP monoclonal antibody | Canine |
| GM-Tg-bovg-SE1099-Ab-1/ GM-Tg-bovg-SE1099-Ab-2 | Anti-Bovine MGP monoclonal antibody | Bovine |
| GM-Tg-equg-SE1099-Ab-1/ GM-Tg-equg-SE1099-Ab-2 | Anti-Equine MGP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1099-Ab-1/ GM-Tg-hg-SE1099-Ab-2; GM-Tg-rg-SE1099-Ab-1/ GM-Tg-rg-SE1099-Ab-2; GM-Tg-mg-SE1099-Ab-1/ GM-Tg-mg-SE1099-Ab-2; GM-Tg-cynog-SE1099-Ab-1/ GM-Tg-cynog-SE1099-Ab-2; GM-Tg-felg-SE1099-Ab-1/ GM-Tg-felg-SE1099-Ab-2; GM-Tg-cang-SE1099-Ab-1/ GM-Tg-cang-SE1099-Ab-2; GM-Tg-bovg-SE1099-Ab-1/ GM-Tg-bovg-SE1099-Ab-2; GM-Tg-equg-SE1099-Ab-1/ GM-Tg-equg-SE1099-Ab-2 |
| Products Name | Anti-MGP monoclonal antibody |
| Format | mab |
| Target Name | MGP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MGP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1099-Ag-1 | Recombinant multi-species MGP/ GIG36/ MGLAP protein |
| ORF Viral Vector | vGMLP004798 | human MGP Lentivirus particle |
| ORF Viral Vector | pGMLP004798 | human MGP Lentivirus plasmid |
| ORF Viral Vector | pGMLV000128 | rat Mgp Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001043 | mouse Mgp Lentivirus plasmid |
| ORF Viral Vector | vGMLV000128 | rat Mgp Lentivirus particle |
| ORF Viral Vector | vGMLPm001043 | mouse Mgp Lentivirus particle |
Target information
| Target ID | GM-SE1099 |
| Target Name | MGP |
| Gene ID | 4256,17313,25333,574116,100856382,101096741,282660,100063934 |
| Gene Symbol and Synonyms | GIG36,MGLAP,MGP,NTI |
| Uniprot Accession | P08493,P08494,P07507 |
| Uniprot Entry Name | MGP_HUMAN,MGP_RAT,MGP_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000111341 |
| Target Classification | N/A |
The target: MGP, gene name: MGP, also named as GIG36, MGLAP, NTI. This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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