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Anti-IL27A/ IL27/ IL-27 functional antibody
Anti-IL27A/ IL27/ IL-27 functional antibody for cell culture, ELISA & in-vivo assay
Go to IL27/IL27 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1026-Ab-1/ GM-Tg-hg-SE1026-Ab-2 | Anti-Human IL27 monoclonal antibody | Human |
| GM-Tg-rg-SE1026-Ab-1/ GM-Tg-rg-SE1026-Ab-2 | Anti-Rat IL27 monoclonal antibody | Rat |
| GM-Tg-mg-SE1026-Ab-1/ GM-Tg-mg-SE1026-Ab-2 | Anti-Mouse IL27 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1026-Ab-1/ GM-Tg-cynog-SE1026-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL27 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1026-Ab-1/ GM-Tg-felg-SE1026-Ab-2 | Anti-Feline IL27 monoclonal antibody | Feline |
| GM-Tg-cang-SE1026-Ab-1/ GM-Tg-cang-SE1026-Ab-2 | Anti-Canine IL27 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1026-Ab-1/ GM-Tg-bovg-SE1026-Ab-2 | Anti-Bovine IL27 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1026-Ab-1/ GM-Tg-equg-SE1026-Ab-2 | Anti-Equine IL27 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1026-Ab-1/ GM-Tg-hg-SE1026-Ab-2; GM-Tg-rg-SE1026-Ab-1/ GM-Tg-rg-SE1026-Ab-2; GM-Tg-mg-SE1026-Ab-1/ GM-Tg-mg-SE1026-Ab-2; GM-Tg-cynog-SE1026-Ab-1/ GM-Tg-cynog-SE1026-Ab-2; GM-Tg-felg-SE1026-Ab-1/ GM-Tg-felg-SE1026-Ab-2; GM-Tg-cang-SE1026-Ab-1/ GM-Tg-cang-SE1026-Ab-2; GM-Tg-bovg-SE1026-Ab-1/ GM-Tg-bovg-SE1026-Ab-2; GM-Tg-equg-SE1026-Ab-1/ GM-Tg-equg-SE1026-Ab-2 |
| Products Name | Anti-IL27 monoclonal antibody |
| Format | mab |
| Target Name | IL27 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL27 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1026-Ag-1 | Recombinant multi-species IL27A/ IL27/ IL-27 protein |
| ORF Viral Vector | vGMLP002772 | human IL27 Lentivirus particle |
| ORF Viral Vector | pGMLP002772 | human IL27 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000395 | mouse Il27 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000395 | mouse Il27 Lentivirus particle |
Target information
| Target ID | GM-SE1026 |
| Target Name | IL27 |
| Gene ID | 246778,246779,365368,708678,607880,101093822,614927,100066317 |
| Gene Symbol and Synonyms | IL-27,IL-27-A,IL-27A,IL-27alpha,IL-27p28,IL27,IL27-A,IL27A,IL27p28,IL30,p28,RGD1561420 |
| Uniprot Accession | Q8NEV9 |
| Uniprot Entry Name | IL27A_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000197272 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: IL27, gene name: IL27, also named as IL-27, IL-27AA, IL27p28, IL30, p28, IL27. The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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