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Anti-FGF3/ HBGF-3/ INT2 functional antibody
Anti-FGF3/ HBGF-3/ INT2 functional antibody for cell culture, ELISA & in-vivo assay
Go to FGF3/FGF3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0921-Ab-1/ GM-Tg-hg-SE0921-Ab-2 | Anti-Human FGF3 monoclonal antibody | Human |
| GM-Tg-rg-SE0921-Ab-1/ GM-Tg-rg-SE0921-Ab-2 | Anti-Rat FGF3 monoclonal antibody | Rat |
| GM-Tg-mg-SE0921-Ab-1/ GM-Tg-mg-SE0921-Ab-2 | Anti-Mouse FGF3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0921-Ab-1/ GM-Tg-cynog-SE0921-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FGF3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0921-Ab-1/ GM-Tg-felg-SE0921-Ab-2 | Anti-Feline FGF3 monoclonal antibody | Feline |
| GM-Tg-cang-SE0921-Ab-1/ GM-Tg-cang-SE0921-Ab-2 | Anti-Canine FGF3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0921-Ab-1/ GM-Tg-bovg-SE0921-Ab-2 | Anti-Bovine FGF3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0921-Ab-1/ GM-Tg-equg-SE0921-Ab-2 | Anti-Equine FGF3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0921-Ab-1/ GM-Tg-hg-SE0921-Ab-2; GM-Tg-rg-SE0921-Ab-1/ GM-Tg-rg-SE0921-Ab-2; GM-Tg-mg-SE0921-Ab-1/ GM-Tg-mg-SE0921-Ab-2; GM-Tg-cynog-SE0921-Ab-1/ GM-Tg-cynog-SE0921-Ab-2; GM-Tg-felg-SE0921-Ab-1/ GM-Tg-felg-SE0921-Ab-2; GM-Tg-cang-SE0921-Ab-1/ GM-Tg-cang-SE0921-Ab-2; GM-Tg-bovg-SE0921-Ab-1/ GM-Tg-bovg-SE0921-Ab-2; GM-Tg-equg-SE0921-Ab-1/ GM-Tg-equg-SE0921-Ab-2 |
| Products Name | Anti-FGF3 monoclonal antibody |
| Format | mab |
| Target Name | FGF3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FGF3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0921-Ag-1 | Recombinant multi-species FGF3/ HBGF-3/ INT2 protein |
| Cytokine | GM-Tg-g-SE0921-Ag-1 | fibroblast growth factor 3 (FGF3) protein |
| ORF Viral Vector | pGMLP004989 | human FGF3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004989 | human FGF3 Lentivirus particle |
| ORF Viral Vector | pGMLPm003743 | mouse Fgf3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003743 | mouse Fgf3 Lentivirus particle |
Target information
| Target ID | GM-SE0921 |
| Target Name | FGF3 |
| Gene ID | 2248,14174,170633,708918,611707,111556666,618481,100146649 |
| Gene Symbol and Synonyms | Fgf-3,FGF3,Fgf5c,HBGF-3,Int-2,Int-P,INT2 |
| Uniprot Accession | P11487 |
| Uniprot Entry Name | FGF3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000186895 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FGF3, gene name: FGF3, also named as HBGF-3, INT2. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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