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Anti-CCL8/ HC14/ MCP-2 functional antibody
Anti-CCL8/ HC14/ MCP-2 functional antibody for cell culture, ELISA & in-vivo assay
Go to CCL8/CCL8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0751-Ab-1/ GM-Tg-hg-SE0751-Ab-2 | Anti-Human CCL8 monoclonal antibody | Human |
| GM-Tg-rg-SE0751-Ab-1/ GM-Tg-rg-SE0751-Ab-2 | Anti-Rat CCL8 monoclonal antibody | Rat |
| GM-Tg-mg-SE0751-Ab-1/ GM-Tg-mg-SE0751-Ab-2 | Anti-Mouse CCL8 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0751-Ab-1/ GM-Tg-cynog-SE0751-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCL8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0751-Ab-1/ GM-Tg-felg-SE0751-Ab-2 | Anti-Feline CCL8 monoclonal antibody | Feline |
| GM-Tg-cang-SE0751-Ab-1/ GM-Tg-cang-SE0751-Ab-2 | Anti-Canine CCL8 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0751-Ab-1/ GM-Tg-bovg-SE0751-Ab-2 | Anti-Bovine CCL8 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0751-Ab-1/ GM-Tg-equg-SE0751-Ab-2 | Anti-Equine CCL8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0751-Ab-1/ GM-Tg-hg-SE0751-Ab-2; GM-Tg-rg-SE0751-Ab-1/ GM-Tg-rg-SE0751-Ab-2; GM-Tg-mg-SE0751-Ab-1/ GM-Tg-mg-SE0751-Ab-2; GM-Tg-cynog-SE0751-Ab-1/ GM-Tg-cynog-SE0751-Ab-2; GM-Tg-felg-SE0751-Ab-1/ GM-Tg-felg-SE0751-Ab-2; GM-Tg-cang-SE0751-Ab-1/ GM-Tg-cang-SE0751-Ab-2; GM-Tg-bovg-SE0751-Ab-1/ GM-Tg-bovg-SE0751-Ab-2; GM-Tg-equg-SE0751-Ab-1/ GM-Tg-equg-SE0751-Ab-2 |
| Products Name | Anti-CCL8 monoclonal antibody |
| Format | mab |
| Target Name | CCL8 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCL8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0751-Ag-1 | Recombinant multi-species CCL8/ HC14/ MCP-2 protein |
| Cytokine | GM-Tg-g-SE0751-Ag-1 | chemokine (C-C motif) ligand 8 (CCL8) protein |
| ORF Viral Vector | vGMLP000800 | human CCL8 Lentivirus particle |
| ORF Viral Vector | pGMLP000800 | human CCL8 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000048 | mouse Ccl8 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000048 | mouse Ccl8 Lentivirus particle |
Target information
| Target ID | GM-SE0751 |
| Target Name | CCL8 |
| Gene ID | 6355,574179,101097189 |
| Gene Symbol and Synonyms | CCL8,HC14,MCP-2,MCP2,SCYA10,SCYA8 |
| Uniprot Accession | P80075 |
| Uniprot Entry Name | CCL8_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000108700 |
| Target Classification | N/A |
The target: CCL8, gene name: CCL8, also named as HC14, MCP-2, MCP2, SCYA10, SCYA8. This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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