Anti-CXCL7/ PPBP/ B-TG1 functional antibody

Anti-CXCL7/ PPBP/ B-TG1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PPBP/PPBP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE0421-Ab-1/ GM-Tg-hg-SE0421-Ab-2Anti-Human PPBP monoclonal antibodyHuman
GM-Tg-rg-SE0421-Ab-1/ GM-Tg-rg-SE0421-Ab-2Anti-Rat PPBP monoclonal antibodyRat
GM-Tg-mg-SE0421-Ab-1/ GM-Tg-mg-SE0421-Ab-2Anti-Mouse PPBP monoclonal antibodyMouse
GM-Tg-cynog-SE0421-Ab-1/ GM-Tg-cynog-SE0421-Ab-2Anti-Cynomolgus/ Rhesus macaque PPBP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE0421-Ab-1/ GM-Tg-felg-SE0421-Ab-2Anti-Feline PPBP monoclonal antibodyFeline
GM-Tg-cang-SE0421-Ab-1/ GM-Tg-cang-SE0421-Ab-2Anti-Canine PPBP monoclonal antibodyCanine
GM-Tg-bovg-SE0421-Ab-1/ GM-Tg-bovg-SE0421-Ab-2Anti-Bovine PPBP monoclonal antibodyBovine
GM-Tg-equg-SE0421-Ab-1/ GM-Tg-equg-SE0421-Ab-2Anti-Equine PPBP monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE0421-Ab-1/ GM-Tg-hg-SE0421-Ab-2; GM-Tg-rg-SE0421-Ab-1/ GM-Tg-rg-SE0421-Ab-2;
GM-Tg-mg-SE0421-Ab-1/ GM-Tg-mg-SE0421-Ab-2; GM-Tg-cynog-SE0421-Ab-1/ GM-Tg-cynog-SE0421-Ab-2;
GM-Tg-felg-SE0421-Ab-1/ GM-Tg-felg-SE0421-Ab-2; GM-Tg-cang-SE0421-Ab-1/ GM-Tg-cang-SE0421-Ab-2;
GM-Tg-bovg-SE0421-Ab-1/ GM-Tg-bovg-SE0421-Ab-2; GM-Tg-equg-SE0421-Ab-1/ GM-Tg-equg-SE0421-Ab-2
Products NameAnti-PPBP monoclonal antibody
Formatmab
Target NamePPBP
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PPBP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE0421-Ag-1Recombinant multi-species CXCL7/ PPBP/ B-TG1 protein
    CytokineGM-Tg-g-SE0421-Ag-1pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) (PPBP) protein
    ORF Viral VectorpGMLP002272human PPBP Lentivirus plasmid
    ORF Viral VectorvGMLP002272human PPBP Lentivirus particle
    ORF Viral VectorpGMLPm000577mouse Ppbp Lentivirus plasmid
    ORF Viral VectorvGMLPm000577mouse Ppbp Lentivirus particle


    Target information

    Target IDGM-SE0421
    Target NamePPBP
    Gene ID5473,703334,101094344,613723,100055973
    Gene Symbol and SynonymsB-TG1,Beta-TG,CTAP-III,CTAP3,CTAPIII,CXCL7,LA-PF4,LDGF,MDGF,NAP-2,PBP,PPBP,SCYB7,TC1,TC2,TGB,TGB1,THBGB,THBGB1
    Uniprot AccessionP02775
    Uniprot Entry NameCXCL7_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryCytokine Target
    DiseaseOvary Cancer, Sepsis, Dent disease, Diabetes type-2
    Gene EnsemblENSG00000163736
    Target ClassificationN/A

    The target: PPBP, gene name: PPBP, also named as B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1. The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.