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Anti-LUM/ LDC/ SLRR2D functional antibody
Anti-LUM/ LDC/ SLRR2D functional antibody for cell culture, ELISA & in-vivo assay
Go to LUM/LUM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0329-Ab-1/ GM-Tg-hg-SE0329-Ab-2 | Anti-Human LUM monoclonal antibody | Human |
| GM-Tg-rg-SE0329-Ab-1/ GM-Tg-rg-SE0329-Ab-2 | Anti-Rat LUM monoclonal antibody | Rat |
| GM-Tg-mg-SE0329-Ab-1/ GM-Tg-mg-SE0329-Ab-2 | Anti-Mouse LUM monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0329-Ab-1/ GM-Tg-cynog-SE0329-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LUM monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0329-Ab-1/ GM-Tg-felg-SE0329-Ab-2 | Anti-Feline LUM monoclonal antibody | Feline |
| GM-Tg-cang-SE0329-Ab-1/ GM-Tg-cang-SE0329-Ab-2 | Anti-Canine LUM monoclonal antibody | Canine |
| GM-Tg-bovg-SE0329-Ab-1/ GM-Tg-bovg-SE0329-Ab-2 | Anti-Bovine LUM monoclonal antibody | Bovine |
| GM-Tg-equg-SE0329-Ab-1/ GM-Tg-equg-SE0329-Ab-2 | Anti-Equine LUM monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0329-Ab-1/ GM-Tg-hg-SE0329-Ab-2; GM-Tg-rg-SE0329-Ab-1/ GM-Tg-rg-SE0329-Ab-2; GM-Tg-mg-SE0329-Ab-1/ GM-Tg-mg-SE0329-Ab-2; GM-Tg-cynog-SE0329-Ab-1/ GM-Tg-cynog-SE0329-Ab-2; GM-Tg-felg-SE0329-Ab-1/ GM-Tg-felg-SE0329-Ab-2; GM-Tg-cang-SE0329-Ab-1/ GM-Tg-cang-SE0329-Ab-2; GM-Tg-bovg-SE0329-Ab-1/ GM-Tg-bovg-SE0329-Ab-2; GM-Tg-equg-SE0329-Ab-1/ GM-Tg-equg-SE0329-Ab-2 |
| Products Name | Anti-LUM monoclonal antibody |
| Format | mab |
| Target Name | LUM |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LUM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0329-Ag-1 | Recombinant multi-species LUM/ LDC/ SLRR2D protein |
| ORF Viral Vector | pGMLP003116 | human LUM Lentivirus plasmid |
| ORF Viral Vector | vGMLP003116 | human LUM Lentivirus particle |
| ORF Viral Vector | pGMLPm002157 | mouse Lum Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002157 | mouse Lum Lentivirus particle |
Target information
| Target ID | GM-SE0329 |
| Target Name | LUM |
| Gene ID | 4060,17022,81682,709830,482599,101100982,280847,100009681 |
| Gene Symbol and Synonyms | LDC,LUM,SLRR2D |
| Uniprot Accession | P51884,P51886,Q05443 |
| Uniprot Entry Name | LUM_HUMAN,LUM_RAT,LUM_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000139329 |
| Target Classification | N/A |
The target: LUM, gene name: LUM, also named as LDC, SLRR2D. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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