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Anti-HEMO/ HPX/ HX functional antibody
Anti-HEMO/ HPX/ HX functional antibody for cell culture, ELISA & in-vivo assay
Go to HPX/HPX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0265-Ab-1/ GM-Tg-hg-SE0265-Ab-2 | Anti-Human HPX monoclonal antibody | Human |
| GM-Tg-rg-SE0265-Ab-1/ GM-Tg-rg-SE0265-Ab-2 | Anti-Rat HPX monoclonal antibody | Rat |
| GM-Tg-mg-SE0265-Ab-1/ GM-Tg-mg-SE0265-Ab-2 | Anti-Mouse HPX monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0265-Ab-1/ GM-Tg-cynog-SE0265-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HPX monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0265-Ab-1/ GM-Tg-felg-SE0265-Ab-2 | Anti-Feline HPX monoclonal antibody | Feline |
| GM-Tg-cang-SE0265-Ab-1/ GM-Tg-cang-SE0265-Ab-2 | Anti-Canine HPX monoclonal antibody | Canine |
| GM-Tg-bovg-SE0265-Ab-1/ GM-Tg-bovg-SE0265-Ab-2 | Anti-Bovine HPX monoclonal antibody | Bovine |
| GM-Tg-equg-SE0265-Ab-1/ GM-Tg-equg-SE0265-Ab-2 | Anti-Equine HPX monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0265-Ab-1/ GM-Tg-hg-SE0265-Ab-2; GM-Tg-rg-SE0265-Ab-1/ GM-Tg-rg-SE0265-Ab-2; GM-Tg-mg-SE0265-Ab-1/ GM-Tg-mg-SE0265-Ab-2; GM-Tg-cynog-SE0265-Ab-1/ GM-Tg-cynog-SE0265-Ab-2; GM-Tg-felg-SE0265-Ab-1/ GM-Tg-felg-SE0265-Ab-2; GM-Tg-cang-SE0265-Ab-1/ GM-Tg-cang-SE0265-Ab-2; GM-Tg-bovg-SE0265-Ab-1/ GM-Tg-bovg-SE0265-Ab-2; GM-Tg-equg-SE0265-Ab-1/ GM-Tg-equg-SE0265-Ab-2 |
| Products Name | Anti-HPX monoclonal antibody |
| Format | mab |
| Target Name | HPX |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HPX benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0265-Ag-1 | Recombinant multi-species HEMO/ HPX/ HX protein |
| ORF Viral Vector | vGMLP003727 | human HPX Lentivirus particle |
| ORF Viral Vector | pGMLP003727 | human HPX Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001838 | mouse Hpx Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001838 | mouse Hpx Lentivirus particle |
Target information
| Target ID | GM-SE0265 |
| Target Name | HPX |
| Gene ID | 3263,15458,58917,711007,610982,101091144,534509,100055123 |
| Gene Symbol and Synonyms | HPX,Hpxn,HX |
| Uniprot Accession | P02790,P20059,Q3SZV7 |
| Uniprot Entry Name | HEMO_HUMAN,HEMO_RAT,HEMO_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Lung cancer, Malignant neoplasm of bladder, Nephrotic syndrome with focal and segmental glomerular lesions, Dent disease, Diabetic Nephropathy |
| Gene Ensembl | ENSG00000110169 |
| Target Classification | N/A |
The target: HPX, gene name: HPX, also named as HX. This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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