Anti-SDHB/ CWS2/ IP monoclonal antibody

Anti-SDHB/ CWS2/ IP antibody for FACS & in-vivo assay

Target products collectionGo to SDHB/SDHB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP2321-Ab-1/ GM-Tg-hg-MP2321-Ab-2Anti-Human SDHB monoclonal antibodyHuman
GM-Tg-rg-MP2321-Ab-1/ GM-Tg-rg-MP2321-Ab-2Anti-Rat SDHB monoclonal antibodyRat
GM-Tg-mg-MP2321-Ab-1/ GM-Tg-mg-MP2321-Ab-2Anti-Mouse SDHB monoclonal antibodyMouse
GM-Tg-cynog-MP2321-Ab-1/ GM-Tg-cynog-MP2321-Ab-2Anti-Cynomolgus/ Rhesus macaque SDHB monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP2321-Ab-1/ GM-Tg-felg-MP2321-Ab-2Anti-Feline SDHB monoclonal antibodyFeline
GM-Tg-cang-MP2321-Ab-1/ GM-Tg-cang-MP2321-Ab-2Anti-Canine SDHB monoclonal antibodyCanine
GM-Tg-bovg-MP2321-Ab-1/ GM-Tg-bovg-MP2321-Ab-2Anti-Bovine SDHB monoclonal antibodyBovine
GM-Tg-equg-MP2321-Ab-1/ GM-Tg-equg-MP2321-Ab-2Anti-Equine SDHB monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP2321-Ab-1/ GM-Tg-hg-MP2321-Ab-2; GM-Tg-rg-MP2321-Ab-1/ GM-Tg-rg-MP2321-Ab-2;
GM-Tg-mg-MP2321-Ab-1/ GM-Tg-mg-MP2321-Ab-2; GM-Tg-cynog-MP2321-Ab-1/ GM-Tg-cynog-MP2321-Ab-2;
GM-Tg-felg-MP2321-Ab-1/ GM-Tg-felg-MP2321-Ab-2; GM-Tg-cang-MP2321-Ab-1/ GM-Tg-cang-MP2321-Ab-2;
GM-Tg-bovg-MP2321-Ab-1/ GM-Tg-bovg-MP2321-Ab-2; GM-Tg-equg-MP2321-Ab-1/ GM-Tg-equg-MP2321-Ab-2
Products NameAnti-SDHB monoclonal antibody
Formatmab
Target NameSDHB
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SDHB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SDHB/ CWS2/ IP VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP005028human SDHB Lentivirus plasmid
    ORF Viral VectorvGMLV000270human SDHB Lentivirus particle
    ORF Viral VectorvGMLP005028human SDHB Lentivirus particle
    ORF Viral VectorpGMLV000270human SDHB Lentivirus plasmid
    ORF Viral VectorpGMLPm002141mouse Sdhb Lentivirus plasmid
    ORF Viral VectorvGMLPm002141mouse Sdhb Lentivirus particle


    Target information

    Target IDGM-MP2321
    Target NameSDHB
    Gene ID6390,67680,298596,699810,478217,751617,286840,100050091
    Gene Symbol and Synonyms0710008N11Rik,CWS2,IP,MC2DN4,PGL4,SDH,SDH1,SDH2,SDHB,SDHIP
    Uniprot AccessionP21912,P21913,Q3T189
    Uniprot Entry NameSDHB_HUMAN,SDHB_RAT,SDHB_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000117118
    Target ClassificationTumor-associated antigen (TAA)

    The target: SDHB, gene name: SDHB, also named as CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP. This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. This enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in this gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorigenesis. Mutations in this gene are also implicated in nuclear type 4 mitochondrial complex II deficiency. [provided by RefSeq, Jun 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.