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Anti-GRP1/ RASGRP1/ CALDAG-GEFI monoclonal antibody
Anti-GRP1/ RASGRP1/ CALDAG-GEFI antibody for FACS & in-vivo assay
Go to RASGRP1/RASGRP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2286-Ab-1/ GM-Tg-hg-MP2286-Ab-2 | Anti-Human RASGRP1 monoclonal antibody | Human |
| GM-Tg-rg-MP2286-Ab-1/ GM-Tg-rg-MP2286-Ab-2 | Anti-Rat RASGRP1 monoclonal antibody | Rat |
| GM-Tg-mg-MP2286-Ab-1/ GM-Tg-mg-MP2286-Ab-2 | Anti-Mouse RASGRP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2286-Ab-1/ GM-Tg-cynog-MP2286-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RASGRP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2286-Ab-1/ GM-Tg-felg-MP2286-Ab-2 | Anti-Feline RASGRP1 monoclonal antibody | Feline |
| GM-Tg-cang-MP2286-Ab-1/ GM-Tg-cang-MP2286-Ab-2 | Anti-Canine RASGRP1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2286-Ab-1/ GM-Tg-bovg-MP2286-Ab-2 | Anti-Bovine RASGRP1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2286-Ab-1/ GM-Tg-equg-MP2286-Ab-2 | Anti-Equine RASGRP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2286-Ab-1/ GM-Tg-hg-MP2286-Ab-2; GM-Tg-rg-MP2286-Ab-1/ GM-Tg-rg-MP2286-Ab-2; GM-Tg-mg-MP2286-Ab-1/ GM-Tg-mg-MP2286-Ab-2; GM-Tg-cynog-MP2286-Ab-1/ GM-Tg-cynog-MP2286-Ab-2; GM-Tg-felg-MP2286-Ab-1/ GM-Tg-felg-MP2286-Ab-2; GM-Tg-cang-MP2286-Ab-1/ GM-Tg-cang-MP2286-Ab-2; GM-Tg-bovg-MP2286-Ab-1/ GM-Tg-bovg-MP2286-Ab-2; GM-Tg-equg-MP2286-Ab-1/ GM-Tg-equg-MP2286-Ab-2 |
| Products Name | Anti-RASGRP1 monoclonal antibody |
| Format | mab |
| Target Name | RASGRP1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RASGRP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GRP1/ RASGRP1/ CALDAG-GEFI VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000208 | human RASGRP1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000208 | human RASGRP1 Lentivirus particle |
Target information
| Target ID | GM-MP2286 |
| Target Name | RASGRP1 |
| Gene ID | 10125,19419,29434,703838,478255,101093110,533125,100071578 |
| Gene Symbol and Synonyms | CALDAG-GEFI,CALDAG-GEFII,IMD64,RASGRP,RASGRP1 |
| Uniprot Accession | O95267,Q9R1K8 |
| Uniprot Entry Name | GRP1_HUMAN,GRP1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000172575 |
| Target Classification | N/A |
The target: RASGRP1, gene name: RASGRP1, also named as CALDAG-GEFI, CALDAG-GEFII, RASGRP. This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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