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Anti-SIGIR/ SIGIRR/ IL-1R8 monoclonal antibody
Anti-SIGIR/ SIGIRR/ IL-1R8 antibody for FACS & in-vivo assay
Go to SIGIRR/SIGIRR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1516-Ab-1/ GM-Tg-hg-MP1516-Ab-2 | Anti-Human SIGIRR monoclonal antibody | Human |
| GM-Tg-rg-MP1516-Ab-1/ GM-Tg-rg-MP1516-Ab-2 | Anti-Rat SIGIRR monoclonal antibody | Rat |
| GM-Tg-mg-MP1516-Ab-1/ GM-Tg-mg-MP1516-Ab-2 | Anti-Mouse SIGIRR monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1516-Ab-1/ GM-Tg-cynog-MP1516-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SIGIRR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1516-Ab-1/ GM-Tg-felg-MP1516-Ab-2 | Anti-Feline SIGIRR monoclonal antibody | Feline |
| GM-Tg-cang-MP1516-Ab-1/ GM-Tg-cang-MP1516-Ab-2 | Anti-Canine SIGIRR monoclonal antibody | Canine |
| GM-Tg-bovg-MP1516-Ab-1/ GM-Tg-bovg-MP1516-Ab-2 | Anti-Bovine SIGIRR monoclonal antibody | Bovine |
| GM-Tg-equg-MP1516-Ab-1/ GM-Tg-equg-MP1516-Ab-2 | Anti-Equine SIGIRR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1516-Ab-1/ GM-Tg-hg-MP1516-Ab-2; GM-Tg-rg-MP1516-Ab-1/ GM-Tg-rg-MP1516-Ab-2; GM-Tg-mg-MP1516-Ab-1/ GM-Tg-mg-MP1516-Ab-2; GM-Tg-cynog-MP1516-Ab-1/ GM-Tg-cynog-MP1516-Ab-2; GM-Tg-felg-MP1516-Ab-1/ GM-Tg-felg-MP1516-Ab-2; GM-Tg-cang-MP1516-Ab-1/ GM-Tg-cang-MP1516-Ab-2; GM-Tg-bovg-MP1516-Ab-1/ GM-Tg-bovg-MP1516-Ab-2; GM-Tg-equg-MP1516-Ab-1/ GM-Tg-equg-MP1516-Ab-2 |
| Products Name | Anti-SIGIRR monoclonal antibody |
| Format | mab |
| Target Name | SIGIRR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SIGIRR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SIGIR/ SIGIRR/ IL-1R8 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP1516-Ag-1 | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (SIGIRR) protein |
| ORF Viral Vector | pGMLV000704 | human SIGIRR Lentivirus plasmid |
| ORF Viral Vector | pGMAP000069 | Human SIGIRR Adenovirus plasmid |
| ORF Viral Vector | vGMAP000069 | Human SIGIRR Adenovirus particle |
| ORF Viral Vector | vGMLV000704 | human SIGIRR Lentivirus particle |
| ORF Viral Vector | pGMAD000320 | mouse Sigirr Adenovirus plasmid |
| ORF Viral Vector | vGMAD000320 | mouse Sigirr Adenovirus particle |
Target information
| Target ID | GM-MP1516 |
| Target Name | SIGIRR |
| Gene ID | 59307,24058,309106,100686933,101100416,531801,100054544 |
| Gene Symbol and Synonyms | IL-1R8,RGD1306732,SIGIRR,TIR8 |
| Uniprot Accession | Q6IA17,Q4V892 |
| Uniprot Entry Name | SIGIR_HUMAN,SIGIR_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000185187 |
| Target Classification | N/A |
The target: SIGIRR, gene name: SIGIRR, also named as IL-1R8, TIR8. Predicted to enable NAD+ nucleosidase activity. Involved in negative regulation of DNA-binding transcription factor activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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