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Anti-RAMP1 monoclonal antibody
Anti-RAMP1 antibody for FACS & in-vivo assay
Go to RAMP1/RAMP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP1451-Ab-1/ GM-Tg-hg-MP1451-Ab-2 | Anti-Human RAMP1 monoclonal antibody | Human |
| GM-Tg-rg-MP1451-Ab-1/ GM-Tg-rg-MP1451-Ab-2 | Anti-Rat RAMP1 monoclonal antibody | Rat |
| GM-Tg-mg-MP1451-Ab-1/ GM-Tg-mg-MP1451-Ab-2 | Anti-Mouse RAMP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP1451-Ab-1/ GM-Tg-cynog-MP1451-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RAMP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP1451-Ab-1/ GM-Tg-felg-MP1451-Ab-2 | Anti-Feline RAMP1 monoclonal antibody | Feline |
| GM-Tg-cang-MP1451-Ab-1/ GM-Tg-cang-MP1451-Ab-2 | Anti-Canine RAMP1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP1451-Ab-1/ GM-Tg-bovg-MP1451-Ab-2 | Anti-Bovine RAMP1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP1451-Ab-1/ GM-Tg-equg-MP1451-Ab-2 | Anti-Equine RAMP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP1451-Ab-1/ GM-Tg-hg-MP1451-Ab-2; GM-Tg-rg-MP1451-Ab-1/ GM-Tg-rg-MP1451-Ab-2; GM-Tg-mg-MP1451-Ab-1/ GM-Tg-mg-MP1451-Ab-2; GM-Tg-cynog-MP1451-Ab-1/ GM-Tg-cynog-MP1451-Ab-2; GM-Tg-felg-MP1451-Ab-1/ GM-Tg-felg-MP1451-Ab-2; GM-Tg-cang-MP1451-Ab-1/ GM-Tg-cang-MP1451-Ab-2; GM-Tg-bovg-MP1451-Ab-1/ GM-Tg-bovg-MP1451-Ab-2; GM-Tg-equg-MP1451-Ab-1/ GM-Tg-equg-MP1451-Ab-2 |
| Products Name | Anti-RAMP1 monoclonal antibody |
| Format | mab |
| Target Name | RAMP1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-RAMP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species RAMP1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP000292 | human RAMP1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000292 | human RAMP1 Lentivirus particle |
| ORF Viral Vector | pGMLPm000169 | mouse Ramp1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000169 | mouse Ramp1 Lentivirus particle |
Target information
| Target ID | GM-MP1451 |
| Target Name | RAMP1 |
| Gene ID | 10267,51801,58965,574329,607163,101092133,617017,100066550 |
| Gene Symbol and Synonyms | 9130218E19Rik,RAMP1 |
| Uniprot Accession | O60894,Q9JJ74 |
| Uniprot Entry Name | RAMP1_HUMAN,RAMP1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000132329 |
| Target Classification | N/A |
The target: RAMP1, gene name: RAMP1, also named as . The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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