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Anti-NPC1/ NPC/ POGZ monoclonal antibody
Anti-NPC1/ NPC/ POGZ antibody for FACS & in-vivo assay
Go to NPC1/NPC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0896-Ab-1/ GM-Tg-hg-MP0896-Ab-2 | Anti-Human NPC1 monoclonal antibody | Human |
| GM-Tg-rg-MP0896-Ab-1/ GM-Tg-rg-MP0896-Ab-2 | Anti-Rat NPC1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0896-Ab-1/ GM-Tg-mg-MP0896-Ab-2 | Anti-Mouse NPC1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0896-Ab-1/ GM-Tg-cynog-MP0896-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NPC1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0896-Ab-1/ GM-Tg-felg-MP0896-Ab-2 | Anti-Feline NPC1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0896-Ab-1/ GM-Tg-cang-MP0896-Ab-2 | Anti-Canine NPC1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0896-Ab-1/ GM-Tg-bovg-MP0896-Ab-2 | Anti-Bovine NPC1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0896-Ab-1/ GM-Tg-equg-MP0896-Ab-2 | Anti-Equine NPC1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0896-Ab-1/ GM-Tg-hg-MP0896-Ab-2; GM-Tg-rg-MP0896-Ab-1/ GM-Tg-rg-MP0896-Ab-2; GM-Tg-mg-MP0896-Ab-1/ GM-Tg-mg-MP0896-Ab-2; GM-Tg-cynog-MP0896-Ab-1/ GM-Tg-cynog-MP0896-Ab-2; GM-Tg-felg-MP0896-Ab-1/ GM-Tg-felg-MP0896-Ab-2; GM-Tg-cang-MP0896-Ab-1/ GM-Tg-cang-MP0896-Ab-2; GM-Tg-bovg-MP0896-Ab-1/ GM-Tg-bovg-MP0896-Ab-2; GM-Tg-equg-MP0896-Ab-1/ GM-Tg-equg-MP0896-Ab-2 |
| Products Name | Anti-NPC1 monoclonal antibody |
| Format | mab |
| Target Name | NPC1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NPC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NPC1/ NPC/ POGZ VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000454 | human NPC1 Lentivirus particle |
| ORF Viral Vector | pGMLV000463 | human NPC1 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000454 | human NPC1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000463 | human NPC1 Lentivirus particle |
Target information
| Target ID | GM-MP0896 |
| Target Name | NPC1 |
| Gene ID | 4864,18145,266732,700835,403698,493693,286772,100059175 |
| Gene Symbol and Synonyms | A430089E03Rik,Cdig2,D18Ertd139e,D18Ertd723e,lcsd,nmf164,NPC,NPC1,POGZ,SLC65A1,SLC66A1,spm |
| Uniprot Accession | O15118 |
| Uniprot Entry Name | NPC1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000141458 |
| Target Classification | N/A |
The target: NPC1, gene name: NPC1, also named as NPC, POGZ, SLC65A1. This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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