Human NPC1/NPC/ POGZ ORF/cDNA clone-Lentivirus particle (NM_000271.4)
Pre-made Human NPC1/NPC/ POGZ Lentiviral expression plasmid for NPC1 lentivirus packaging, NPC1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.
The GM Vector Core (GMVC) specializes in custom lentivirus development and offers a range of lentivirus manufacturing solutions, leveraging state-of-the-art processes. Learn more about our services.
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Product information
Catalog No. | Product Name | lentivirus Grade | lentivirus quantity |
---|---|---|---|
vGMLV000463 | Human NPC1 Lentivirus particle | Pilot Grade | 1.0E+8TU |
5.0E+8TU | |||
1.0E+9TU | |||
Research Grade | 1.0E+8TU | ||
5.0E+8TU | |||
1.0E+9TU | |||
GMP-like Grade | inquiry | ||
GMP Grade | inquiry |
Product Description
Catalog ID | vGMLV000463 |
Gene Name | NPC1 |
Accession Number | NM_000271.4 |
Gene ID | 4864 |
Species | Human |
Product Type | Lentivirus particle (overexpression) |
Insert Length | 3837 bp |
Gene Alias | NPC, POGZ, SLC65A1 |
Fluorescent Reporter | ZsGreen |
Mammalian Cell Selection | Puromyocinmyocin |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
---|---|---|
Target Antibody | GM-Tg-g-MP0896-Ab | Anti-NPC1/ NPC/ POGZ monoclonal antibody |
Target Antigen | GM-Tg-g-MP0896-Ag | NPC1 VLP (virus-like particle) |
ORF Viral Vector | pGMLV000454 | Human NPC1 Lentivirus plasmid |
ORF Viral Vector | pGMLV000463 | Human NPC1 Lentivirus plasmid |
ORF Viral Vector | vGMLV000454 | Human NPC1 Lentivirus particle |
ORF Viral Vector | vGMLV000463 | Human NPC1 Lentivirus particle |
Target information
Target ID | GM-MP0896 |
Target Name | NPC1 |
Gene ID | 4864, 18145, 700835, 266732, 493693, 403698, 286772, 100059175 |
Gene Symbol and Synonyms | A430089E03Rik,Cdig2,D18Ertd139e,D18Ertd723e,lcsd,nmf164,NPC,NPC1,POGZ,SLC65A1,SLC66A1,spm |
Uniprot Accession | O15118 |
Uniprot Entry Name | NPC1_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Not Available |
Disease | Not Available |
Gene Ensembl | ENSG00000141458 |
Target Classification | Not Available |
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
About GMVC
GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.