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Anti-AMRP/ LRPAP1/ A2MRAP monoclonal antibody
Anti-AMRP/ LRPAP1/ A2MRAP antibody for FACS & in-vivo assay
Go to LRPAP1/LRPAP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0759-Ab-1/ GM-Tg-hg-MP0759-Ab-2 | Anti-Human LRPAP1 monoclonal antibody | Human |
| GM-Tg-rg-MP0759-Ab-1/ GM-Tg-rg-MP0759-Ab-2 | Anti-Rat LRPAP1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0759-Ab-1/ GM-Tg-mg-MP0759-Ab-2 | Anti-Mouse LRPAP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0759-Ab-1/ GM-Tg-cynog-MP0759-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LRPAP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0759-Ab-1/ GM-Tg-felg-MP0759-Ab-2 | Anti-Feline LRPAP1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0759-Ab-1/ GM-Tg-cang-MP0759-Ab-2 | Anti-Canine LRPAP1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0759-Ab-1/ GM-Tg-bovg-MP0759-Ab-2 | Anti-Bovine LRPAP1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0759-Ab-1/ GM-Tg-equg-MP0759-Ab-2 | Anti-Equine LRPAP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0759-Ab-1/ GM-Tg-hg-MP0759-Ab-2; GM-Tg-rg-MP0759-Ab-1/ GM-Tg-rg-MP0759-Ab-2; GM-Tg-mg-MP0759-Ab-1/ GM-Tg-mg-MP0759-Ab-2; GM-Tg-cynog-MP0759-Ab-1/ GM-Tg-cynog-MP0759-Ab-2; GM-Tg-felg-MP0759-Ab-1/ GM-Tg-felg-MP0759-Ab-2; GM-Tg-cang-MP0759-Ab-1/ GM-Tg-cang-MP0759-Ab-2; GM-Tg-bovg-MP0759-Ab-1/ GM-Tg-bovg-MP0759-Ab-2; GM-Tg-equg-MP0759-Ab-1/ GM-Tg-equg-MP0759-Ab-2 |
| Products Name | Anti-LRPAP1 monoclonal antibody |
| Format | mab |
| Target Name | LRPAP1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LRPAP1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AMRP/ LRPAP1/ A2MRAP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003583 | human LRPAP1 Lentivirus particle |
| ORF Viral Vector | pGMLP003583 | human LRPAP1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002783 | mouse Lrpap1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002783 | mouse Lrpap1 Lentivirus particle |
Target information
| Target ID | GM-MP0759 |
| Target Name | LRPAP1 |
| Gene ID | 4043,16976,116565,699677,479072,101087737,504957,100054064 |
| Gene Symbol and Synonyms | A2MRAP,A2RAP,alpha-2-MRAP,HBP44,LRPAP1,MRAP,MYP23,RAP |
| Uniprot Accession | P30533,Q99068 |
| Uniprot Entry Name | AMRP_HUMAN,AMRP_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000163956 |
| Target Classification | N/A |
The target: LRPAP1, gene name: LRPAP1, also named as A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP. This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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