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Anti-LITAF/ PIG7/ SIMPLE monoclonal antibody
Anti-LITAF/ PIG7/ SIMPLE antibody for FACS & in-vivo assay
Go to LITAF/LITAF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0737-Ab-1/ GM-Tg-hg-MP0737-Ab-2 | Anti-Human LITAF monoclonal antibody | Human |
| GM-Tg-rg-MP0737-Ab-1/ GM-Tg-rg-MP0737-Ab-2 | Anti-Rat LITAF monoclonal antibody | Rat |
| GM-Tg-mg-MP0737-Ab-1/ GM-Tg-mg-MP0737-Ab-2 | Anti-Mouse LITAF monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0737-Ab-1/ GM-Tg-cynog-MP0737-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LITAF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0737-Ab-1/ GM-Tg-felg-MP0737-Ab-2 | Anti-Feline LITAF monoclonal antibody | Feline |
| GM-Tg-cang-MP0737-Ab-1/ GM-Tg-cang-MP0737-Ab-2 | Anti-Canine LITAF monoclonal antibody | Canine |
| GM-Tg-bovg-MP0737-Ab-1/ GM-Tg-bovg-MP0737-Ab-2 | Anti-Bovine LITAF monoclonal antibody | Bovine |
| GM-Tg-equg-MP0737-Ab-1/ GM-Tg-equg-MP0737-Ab-2 | Anti-Equine LITAF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0737-Ab-1/ GM-Tg-hg-MP0737-Ab-2; GM-Tg-rg-MP0737-Ab-1/ GM-Tg-rg-MP0737-Ab-2; GM-Tg-mg-MP0737-Ab-1/ GM-Tg-mg-MP0737-Ab-2; GM-Tg-cynog-MP0737-Ab-1/ GM-Tg-cynog-MP0737-Ab-2; GM-Tg-felg-MP0737-Ab-1/ GM-Tg-felg-MP0737-Ab-2; GM-Tg-cang-MP0737-Ab-1/ GM-Tg-cang-MP0737-Ab-2; GM-Tg-bovg-MP0737-Ab-1/ GM-Tg-bovg-MP0737-Ab-2; GM-Tg-equg-MP0737-Ab-1/ GM-Tg-equg-MP0737-Ab-2 |
| Products Name | Anti-LITAF monoclonal antibody |
| Format | mab |
| Target Name | LITAF |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LITAF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LITAF/ PIG7/ SIMPLE VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002939 | human LITAF Lentivirus plasmid |
| ORF Viral Vector | vGMLP002939 | human LITAF Lentivirus particle |
| ORF Viral Vector | pGMLPm000655 | mouse Litaf Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000655 | mouse Litaf Lentivirus particle |
Target information
| Target ID | GM-MP0737 |
| Target Name | LITAF |
| Gene ID | 9516,56722,65161,711743,490004,101083562,520564,100033923 |
| Gene Symbol and Synonyms | 3222402J11Rik,EET-1,LITAF,N4WBP3,PIG7,SIMPLE,TBX1,TP53I7 |
| Uniprot Accession | Q99732,P0C0T0 |
| Uniprot Entry Name | LITAF_HUMAN,LITAF_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000189067 |
| Target Classification | N/A |
The target: LITAF, gene name: LITAF, also named as PIG7, SIMPLE, TP53I7. Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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