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Anti-I22R1/ IL22RA1/ CRF2-9 monoclonal antibody
Anti-I22R1/ IL22RA1/ CRF2-9 antibody for FACS & in-vivo assay
Go to IL22RA1/IL22RA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0625-Ab-1/ GM-Tg-hg-MP0625-Ab-2 | Anti-Human IL22RA1 monoclonal antibody | Human |
| GM-Tg-rg-MP0625-Ab-1/ GM-Tg-rg-MP0625-Ab-2 | Anti-Rat IL22RA1 monoclonal antibody | Rat |
| GM-Tg-mg-MP0625-Ab-1/ GM-Tg-mg-MP0625-Ab-2 | Anti-Mouse IL22RA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0625-Ab-1/ GM-Tg-cynog-MP0625-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL22RA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0625-Ab-1/ GM-Tg-felg-MP0625-Ab-2 | Anti-Feline IL22RA1 monoclonal antibody | Feline |
| GM-Tg-cang-MP0625-Ab-1/ GM-Tg-cang-MP0625-Ab-2 | Anti-Canine IL22RA1 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0625-Ab-1/ GM-Tg-bovg-MP0625-Ab-2 | Anti-Bovine IL22RA1 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0625-Ab-1/ GM-Tg-equg-MP0625-Ab-2 | Anti-Equine IL22RA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0625-Ab-1/ GM-Tg-hg-MP0625-Ab-2; GM-Tg-rg-MP0625-Ab-1/ GM-Tg-rg-MP0625-Ab-2; GM-Tg-mg-MP0625-Ab-1/ GM-Tg-mg-MP0625-Ab-2; GM-Tg-cynog-MP0625-Ab-1/ GM-Tg-cynog-MP0625-Ab-2; GM-Tg-felg-MP0625-Ab-1/ GM-Tg-felg-MP0625-Ab-2; GM-Tg-cang-MP0625-Ab-1/ GM-Tg-cang-MP0625-Ab-2; GM-Tg-bovg-MP0625-Ab-1/ GM-Tg-bovg-MP0625-Ab-2; GM-Tg-equg-MP0625-Ab-1/ GM-Tg-equg-MP0625-Ab-2 |
| Products Name | Anti-IL22RA1 monoclonal antibody |
| Format | mab |
| Target Name | IL22RA1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL22RA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-821 | Pre-Made Efmarodocokin Alfa Biosimilar, Fusion Protein targeting IL22RA1/IL22R1 fused with human IGHG4 Fc (Fragment constant): Recombinant therapeutic protein targeting CRF2-9 |
| Target Antigen | Products Developing | Multi-species I22R1/ IL22RA1/ CRF2-9 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0625-Ag-1 | interleukin 22 receptor, alpha 1 (IL22RA1) protein |
| ORF Viral Vector | pGMLV000689 | human IL22RA1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000689 | human IL22RA1 Lentivirus particle |
| ORF Viral Vector | vGMAD000641 | human IL22RA1 Adenovirus particle |
| ORF Viral Vector | pGMAD000641 | human IL22RA1 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm005362 | mouse Il22ra1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005362 | mouse Il22ra1 Lentivirus particle |
Target information
| Target ID | GM-MP0625 |
| Target Name | IL22RA1 |
| Gene ID | 58985,230828,362629,719264,612279,101100741,508044,100071510 |
| Gene Symbol and Synonyms | 9130219A07Rik,CRF2-9,IL-22R,IL22R,IL22R1,IL22RA1,RGD1559655 |
| Uniprot Accession | Q8N6P7,Q3SYS8 |
| Uniprot Entry Name | I22R1_HUMAN,I22R1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000142677 |
| Target Classification | N/A |
The target: IL22RA1, gene name: IL22RA1, also named as CRF2-9, IL22R, IL22R1. The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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