Anti-ILRL1/ IL1RL1/ DER4 monoclonal antibody

Anti-ILRL1/ IL1RL1/ DER4 antibody for FACS & in-vivo assay

Target products collectionGo to IL1RL1/IL1RL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0622-Ab-1/ GM-Tg-hg-MP0622-Ab-2Anti-Human IL1RL1 monoclonal antibodyHuman
GM-Tg-rg-MP0622-Ab-1/ GM-Tg-rg-MP0622-Ab-2Anti-Rat IL1RL1 monoclonal antibodyRat
GM-Tg-mg-MP0622-Ab-1/ GM-Tg-mg-MP0622-Ab-2Anti-Mouse IL1RL1 monoclonal antibodyMouse
GM-Tg-cynog-MP0622-Ab-1/ GM-Tg-cynog-MP0622-Ab-2Anti-Cynomolgus/ Rhesus macaque IL1RL1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0622-Ab-1/ GM-Tg-felg-MP0622-Ab-2Anti-Feline IL1RL1 monoclonal antibodyFeline
GM-Tg-cang-MP0622-Ab-1/ GM-Tg-cang-MP0622-Ab-2Anti-Canine IL1RL1 monoclonal antibodyCanine
GM-Tg-bovg-MP0622-Ab-1/ GM-Tg-bovg-MP0622-Ab-2Anti-Bovine IL1RL1 monoclonal antibodyBovine
GM-Tg-equg-MP0622-Ab-1/ GM-Tg-equg-MP0622-Ab-2Anti-Equine IL1RL1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0622-Ab-1/ GM-Tg-hg-MP0622-Ab-2; GM-Tg-rg-MP0622-Ab-1/ GM-Tg-rg-MP0622-Ab-2;
GM-Tg-mg-MP0622-Ab-1/ GM-Tg-mg-MP0622-Ab-2; GM-Tg-cynog-MP0622-Ab-1/ GM-Tg-cynog-MP0622-Ab-2;
GM-Tg-felg-MP0622-Ab-1/ GM-Tg-felg-MP0622-Ab-2; GM-Tg-cang-MP0622-Ab-1/ GM-Tg-cang-MP0622-Ab-2;
GM-Tg-bovg-MP0622-Ab-1/ GM-Tg-bovg-MP0622-Ab-2; GM-Tg-equg-MP0622-Ab-1/ GM-Tg-equg-MP0622-Ab-2
Products NameAnti-IL1RL1 monoclonal antibody
Formatmab
Target NameIL1RL1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL1RL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-033Pre-Made Astegolimab biosimilar, Whole mAb, Anti-IL1RL1/ST2 Antibody: Anti-DER4/FIT-1/IL33R/T1 therapeutic antibody
    BiosimilarGMP-Bios-ab-340Pre-Made Melrilimab biosimilar, Whole mAb, Anti-IL1RL1/ST2 Antibody: Anti-DER4/FIT-1/IL33R/T1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species ILRL1/ IL1RL1/ DER4 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-MP0622-Ag-1interleukin 1 receptor-like 1 (IL1RL1) protein
    ORF Viral VectorpGMLP003795human IL1RL1 Lentivirus plasmid
    ORF Viral VectorvGMLP003795human IL1RL1 Lentivirus particle
    ORF Viral VectorpGMAAV000249house mouse Il1rl1 AAV plasmid
    ORF Viral VectorvGMAAV000249house mouse Il1rl1 AAV particle


    Target information

    Target IDGM-MP0622
    Target NameIL1RL1
    Gene ID9173,17082,25556,711893,611442,101080448,520709,100058357
    Gene Symbol and SynonymsDER4,FIT-1,FIT1,IL1RL1,IL33R,Ly84,ST2,St2-rs1,ST2L,ST2V,T1,T1/ST2
    Uniprot AccessionQ01638,Q62611
    Uniprot Entry NameILRL1_HUMAN,ILRL1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000115602
    Target ClassificationTumor-associated antigen (TAA)

    The target: IL1RL1, gene name: IL1RL1, also named as DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1. The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.