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Anti-GFRA2/ GDNFRB/ NRTNR-ALPHA monoclonal antibody
Anti-GFRA2/ GDNFRB/ NRTNR-ALPHA antibody for FACS & in-vivo assay
Go to GFRA2/GFRA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0479-Ab-1/ GM-Tg-hg-MP0479-Ab-2 | Anti-Human GFRA2 monoclonal antibody | Human |
| GM-Tg-rg-MP0479-Ab-1/ GM-Tg-rg-MP0479-Ab-2 | Anti-Rat GFRA2 monoclonal antibody | Rat |
| GM-Tg-mg-MP0479-Ab-1/ GM-Tg-mg-MP0479-Ab-2 | Anti-Mouse GFRA2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0479-Ab-1/ GM-Tg-cynog-MP0479-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GFRA2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0479-Ab-1/ GM-Tg-felg-MP0479-Ab-2 | Anti-Feline GFRA2 monoclonal antibody | Feline |
| GM-Tg-cang-MP0479-Ab-1/ GM-Tg-cang-MP0479-Ab-2 | Anti-Canine GFRA2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0479-Ab-1/ GM-Tg-bovg-MP0479-Ab-2 | Anti-Bovine GFRA2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0479-Ab-1/ GM-Tg-equg-MP0479-Ab-2 | Anti-Equine GFRA2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0479-Ab-1/ GM-Tg-hg-MP0479-Ab-2; GM-Tg-rg-MP0479-Ab-1/ GM-Tg-rg-MP0479-Ab-2; GM-Tg-mg-MP0479-Ab-1/ GM-Tg-mg-MP0479-Ab-2; GM-Tg-cynog-MP0479-Ab-1/ GM-Tg-cynog-MP0479-Ab-2; GM-Tg-felg-MP0479-Ab-1/ GM-Tg-felg-MP0479-Ab-2; GM-Tg-cang-MP0479-Ab-1/ GM-Tg-cang-MP0479-Ab-2; GM-Tg-bovg-MP0479-Ab-1/ GM-Tg-bovg-MP0479-Ab-2; GM-Tg-equg-MP0479-Ab-1/ GM-Tg-equg-MP0479-Ab-2 |
| Products Name | Anti-GFRA2 monoclonal antibody |
| Format | mab |
| Target Name | GFRA2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GFRA2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GFRA2/ GDNFRB/ NRTNR-ALPHA VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0479-Ag-1 | GDNF family receptor alpha 2 (GFRA2) protein |
| ORF Viral Vector | pGMLP002235 | human GFRA2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002235 | human GFRA2 Lentivirus particle |
Target information
| Target ID | GM-MP0479 |
| Target Name | GFRA2 |
| Gene ID | 2675,14586,25136,715110,609172,101091865,514036,100146260 |
| Gene Symbol and Synonyms | GDNFRB,GFRA2,NRTNR-ALPHA,NTNRA,RETL2,TRNR2 |
| Uniprot Accession | O00451,Q5E9X0 |
| Uniprot Entry Name | GFRA2_HUMAN,GFRA2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000168546 |
| Target Classification | N/A |
The target: GFRA2, gene name: GFRA2, also named as GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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