Human GFRA2/GDNFRB/NRTNR-ALPHA ORF/cDNA clone-Lentivirus plasmid (NM_001495)

Cat. No.: pGMLP002235
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human GFRA2/GDNFRB/NRTNR-ALPHA Lentiviral expression plasmid for GFRA2 lentivirus packaging, GFRA2 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP002235
Gene Name GFRA2
Accession Number NM_001495
Gene ID 2675
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 1395 bp
Gene Alias GDNFRB,NRTNR-ALPHA,NTNRA,RETL2,TRNR2
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGATCTTGGCAAACGTCTTCTGCCTCTTCTTCTTTCTAGACGAGACCCTCCGCTCTTTGGCCAGCCCTTCCTCCCTGCAGGGCCCCGAGCTCCACGGCTGGCGCCCCCCAGTGGACTGTGTCCGGGCCAATGAGCTGTGTGCCGCCGAATCCAACTGCAGCTCTCGCTACCGCACTCTGCGGCAGTGCCTGGCAGGCCGCGACCGCAACACCATGCTGGCCAACAAGGAGTGCCAGGCGGCCTTGGAGGTCTTGCAGGAGAGCCCGCTGTACGACTGCCGCTGCAAGCGGGGCATGAAGAAGGAGCTGCAGTGTCTGCAGATCTACTGGAGCATCCACCTGGGGCTGACCGAGGGTGAGGAGTTCTACGAAGCCTCCCCCTATGAGCCGGTGACCTCCCGCCTCTCGGACATCTTCAGGCTTGCTTCAATCTTCTCAGGGACAGGGGCAGACCCGGTGGTCAGCGCCAAGAGCAACCATTGCCTGGATGCTGCCAAGGCCTGCAACCTGAATGACAACTGCAAGAAGCTGCGCTCCTCCTACATCTCCATCTGCAACCGCGAGATCTCGCCCACCGAGCGCTGCAACCGCCGCAAGTGCCACAAGGCCCTGCGCCAGTTCTTCGACCGGGTGCCCAGCGAGTACACCTACCGCATGCTCTTCTGCTCCTGCCAAGACCAGGCGTGCGCTGAGCGCCGCCGGCAAACCATCCTGCCCAGCTGCTCCTATGAGGACAAGGAGAAGCCCAACTGCCTGGACCTGCGTGGCGTGTGCCGGACTGACCACCTGTGTCGGTCCCGGCTGGCCGACTTCCATGCCAATTGTCGAGCCTCCTACCAGACGGTCACCAGCTGCCCTGCGGACAATTACCAGGCGTGTCTGGGCTCTTATGCTGGCATGATTGGGTTTGACATGACACCTAACTATGTGGACTCCAGCCCCACTGGCATCGTGGTGTCCCCCTGGTGCAGCTGTCGTGGCAGCGGGAACATGGAGGAGGAGTGTGAGAAGTTCCTCAGGGACTTCACCGAGAACCCATGCCTCCGGAACGCCATCCAGGCCTTTGGCAACGGCACGGACGTGAACGTGTCCCCAAAAGGCCCCTCGTTCCAGGCCACCCAGGCCCCTCGGGTGGAGAAGACGCCTTCTTTGCCAGATGACCTCAGTGACAGTACCAGCTTGGGGACCAGTGTCATCACCACCTGCACGTCTGTCCAGGAGCAGGGGCTGAAGGCCAACAACTCCAAAGAGTTAAGCATGTGCTTCACAGAGCTCACGACAAATATCATCCCAGGGAGTAACAAGGTGATCAAACCTAACTCAGGCCCCAGCAGAGCCAGACCGTCGGCTGCCTTGACCGTGCTGTCTGTCCTGATGCTGAAACTGGCCTTGTAG
ORF Protein Sequence MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-MP0479-Ab Anti-GFRA2/ GDNFRB/ NRTNR-ALPHA monoclonal antibody
    Target Antigen GM-Tg-g-MP0479-Ag GFRA2 VLP (virus-like particle)
    Cytokine cks-Tg-g-GM-MP0479 GDNF family receptor alpha 2 (GFRA2) protein & antibody
    ORF Viral Vector pGMLP002235 Human GFRA2 Lentivirus plasmid
    ORF Viral Vector vGMLP002235 Human GFRA2 Lentivirus particle


    Target information

    Target ID GM-MP0479
    Target Name GFRA2
    Gene ID 2675, 14586, 715110, 25136, 101091865, 609172, 514036, 100146260
    Gene Symbol and Synonyms GDNFRB,GFRA2,NRTNR-ALPHA,NTNRA,RETL2,TRNR2
    Uniprot Accession O00451
    Uniprot Entry Name GFRA2_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Cytokine Target
    Disease Not Available
    Gene Ensembl ENSG00000168546
    Target Classification Not Available

    Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]



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