Anti-GFRA1/ GDNFR/ GDNFRA monoclonal antibody

Anti-GFRA1/ GDNFR/ GDNFRA antibody for FACS & in-vivo assay

Target products collectionGo to GFRA1/GFRA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0478-Ab-1/ GM-Tg-hg-MP0478-Ab-2Anti-Human GFRA1 monoclonal antibodyHuman
GM-Tg-rg-MP0478-Ab-1/ GM-Tg-rg-MP0478-Ab-2Anti-Rat GFRA1 monoclonal antibodyRat
GM-Tg-mg-MP0478-Ab-1/ GM-Tg-mg-MP0478-Ab-2Anti-Mouse GFRA1 monoclonal antibodyMouse
GM-Tg-cynog-MP0478-Ab-1/ GM-Tg-cynog-MP0478-Ab-2Anti-Cynomolgus/ Rhesus macaque GFRA1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0478-Ab-1/ GM-Tg-felg-MP0478-Ab-2Anti-Feline GFRA1 monoclonal antibodyFeline
GM-Tg-cang-MP0478-Ab-1/ GM-Tg-cang-MP0478-Ab-2Anti-Canine GFRA1 monoclonal antibodyCanine
GM-Tg-bovg-MP0478-Ab-1/ GM-Tg-bovg-MP0478-Ab-2Anti-Bovine GFRA1 monoclonal antibodyBovine
GM-Tg-equg-MP0478-Ab-1/ GM-Tg-equg-MP0478-Ab-2Anti-Equine GFRA1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0478-Ab-1/ GM-Tg-hg-MP0478-Ab-2; GM-Tg-rg-MP0478-Ab-1/ GM-Tg-rg-MP0478-Ab-2;
GM-Tg-mg-MP0478-Ab-1/ GM-Tg-mg-MP0478-Ab-2; GM-Tg-cynog-MP0478-Ab-1/ GM-Tg-cynog-MP0478-Ab-2;
GM-Tg-felg-MP0478-Ab-1/ GM-Tg-felg-MP0478-Ab-2; GM-Tg-cang-MP0478-Ab-1/ GM-Tg-cang-MP0478-Ab-2;
GM-Tg-bovg-MP0478-Ab-1/ GM-Tg-bovg-MP0478-Ab-2; GM-Tg-equg-MP0478-Ab-1/ GM-Tg-equg-MP0478-Ab-2
Products NameAnti-GFRA1 monoclonal antibody
Formatmab
Target NameGFRA1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GFRA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GFRA1/ GDNFR/ GDNFRA VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-MP0478-Ag-1GDNF family receptor alpha 1 (GFRA1) protein
    ORF Viral VectorpGMLP001513human GFRA1 Lentivirus plasmid
    ORF Viral VectorvGMLP001513human GFRA1 Lentivirus particle
    ORF Viral VectorpGMLPm001786mouse Gfra1 Lentivirus plasmid
    ORF Viral VectorvGMLPm001786mouse Gfra1 Lentivirus particle


    Target information

    Target IDGM-MP0478
    Target NameGFRA1
    Gene ID2674,14585,25454,706353,609114,101085242,534801,100067810
    Gene Symbol and SynonymsGDNFR,GDNFR-alpha-1,GDNFRA,GFR-ALPHA-1,GFRA1,GFRalpha-1,RET1L,RETL1,RHDA4,TRNR1
    Uniprot AccessionP56159,Q62997
    Uniprot Entry NameGFRA1_HUMAN,GFRA1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryCytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000151892
    Target ClassificationN/A

    The target: GFRA1, gene name: GFRA1, also named as GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1. This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.