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Anti-CCR10/ GPR2 monoclonal antibody
Anti-CCR10/ GPR2 antibody for FACS & in-vivo assay
Go to CCR10/CCR10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0189-Ab-1/ GM-Tg-hg-MP0189-Ab-2 | Anti-Human CCR10 monoclonal antibody | Human |
| GM-Tg-rg-MP0189-Ab-1/ GM-Tg-rg-MP0189-Ab-2 | Anti-Rat CCR10 monoclonal antibody | Rat |
| GM-Tg-mg-MP0189-Ab-1/ GM-Tg-mg-MP0189-Ab-2 | Anti-Mouse CCR10 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0189-Ab-1/ GM-Tg-cynog-MP0189-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCR10 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0189-Ab-1/ GM-Tg-felg-MP0189-Ab-2 | Anti-Feline CCR10 monoclonal antibody | Feline |
| GM-Tg-cang-MP0189-Ab-1/ GM-Tg-cang-MP0189-Ab-2 | Anti-Canine CCR10 monoclonal antibody | Canine |
| GM-Tg-bovg-MP0189-Ab-1/ GM-Tg-bovg-MP0189-Ab-2 | Anti-Bovine CCR10 monoclonal antibody | Bovine |
| GM-Tg-equg-MP0189-Ab-1/ GM-Tg-equg-MP0189-Ab-2 | Anti-Equine CCR10 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0189-Ab-1/ GM-Tg-hg-MP0189-Ab-2; GM-Tg-rg-MP0189-Ab-1/ GM-Tg-rg-MP0189-Ab-2; GM-Tg-mg-MP0189-Ab-1/ GM-Tg-mg-MP0189-Ab-2; GM-Tg-cynog-MP0189-Ab-1/ GM-Tg-cynog-MP0189-Ab-2; GM-Tg-felg-MP0189-Ab-1/ GM-Tg-felg-MP0189-Ab-2; GM-Tg-cang-MP0189-Ab-1/ GM-Tg-cang-MP0189-Ab-2; GM-Tg-bovg-MP0189-Ab-1/ GM-Tg-bovg-MP0189-Ab-2; GM-Tg-equg-MP0189-Ab-1/ GM-Tg-equg-MP0189-Ab-2 |
| Products Name | Anti-CCR10 monoclonal antibody |
| Format | mab |
| Target Name | CCR10 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCR10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CCR10/ GPR2 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP0189-Ag-1 | chemokine (C-C motif) receptor 10 (CCR10) protein |
| ORF Viral Vector | vGMLP001466 | human CCR10 Lentivirus particle |
| ORF Viral Vector | pGMLP001466 | human CCR10 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005316 | mouse Ccr10 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005316 | mouse Ccr10 Lentivirus particle |
Target information
| Target ID | GM-MP0189 |
| Target Name | CCR10 |
| Gene ID | 2826,12777,363682,711255,607528,101092409,539108,100065946 |
| Gene Symbol and Synonyms | C-C CKR-10,CC-CKR-10,CCR-10,CCR10,Cmkbr9,GPR2 |
| Uniprot Accession | P46092 |
| Uniprot Entry Name | CCR10_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000184451 |
| Target Classification | N/A |
The target: CCR10, gene name: CCR10, also named as GPR2. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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