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Anti-AMNLS/ AMN/ PRO1028 monoclonal antibody
Anti-AMNLS/ AMN/ PRO1028 antibody for FACS & in-vivo assay
Go to AMN/AMN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0058-Ab-1/ GM-Tg-hg-MP0058-Ab-2 | Anti-Human AMN monoclonal antibody | Human |
| GM-Tg-rg-MP0058-Ab-1/ GM-Tg-rg-MP0058-Ab-2 | Anti-Rat AMN monoclonal antibody | Rat |
| GM-Tg-mg-MP0058-Ab-1/ GM-Tg-mg-MP0058-Ab-2 | Anti-Mouse AMN monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0058-Ab-1/ GM-Tg-cynog-MP0058-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AMN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0058-Ab-1/ GM-Tg-felg-MP0058-Ab-2 | Anti-Feline AMN monoclonal antibody | Feline |
| GM-Tg-cang-MP0058-Ab-1/ GM-Tg-cang-MP0058-Ab-2 | Anti-Canine AMN monoclonal antibody | Canine |
| GM-Tg-bovg-MP0058-Ab-1/ GM-Tg-bovg-MP0058-Ab-2 | Anti-Bovine AMN monoclonal antibody | Bovine |
| GM-Tg-equg-MP0058-Ab-1/ GM-Tg-equg-MP0058-Ab-2 | Anti-Equine AMN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0058-Ab-1/ GM-Tg-hg-MP0058-Ab-2; GM-Tg-rg-MP0058-Ab-1/ GM-Tg-rg-MP0058-Ab-2; GM-Tg-mg-MP0058-Ab-1/ GM-Tg-mg-MP0058-Ab-2; GM-Tg-cynog-MP0058-Ab-1/ GM-Tg-cynog-MP0058-Ab-2; GM-Tg-felg-MP0058-Ab-1/ GM-Tg-felg-MP0058-Ab-2; GM-Tg-cang-MP0058-Ab-1/ GM-Tg-cang-MP0058-Ab-2; GM-Tg-bovg-MP0058-Ab-1/ GM-Tg-bovg-MP0058-Ab-2; GM-Tg-equg-MP0058-Ab-1/ GM-Tg-equg-MP0058-Ab-2 |
| Products Name | Anti-AMN monoclonal antibody |
| Format | mab |
| Target Name | AMN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AMN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AMNLS/ AMN/ PRO1028 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001763 | human AMN Lentivirus particle |
| ORF Viral Vector | pGMLP001763 | human AMN Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001853 | mouse Amn Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001853 | mouse Amn Lentivirus particle |
Target information
| Target ID | GM-MP0058 |
| Target Name | AMN |
| Gene ID | 81693,93835,314459,106999578,403434,101084117,767976,106782539 |
| Gene Symbol and Synonyms | AMN,amnionless,IGS2,PRO1028 |
| Uniprot Accession | Q9BXJ7,Q6UKI2 |
| Uniprot Entry Name | AMNLS_HUMAN,AMNLS_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000166126 |
| Target Classification | N/A |
The target: AMN, gene name: AMN, also named as PRO1028, amnionless. The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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