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Anti-GCLC monoclonal antibody
Pre-made anti-GCLC monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to GCLC/GCLC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0890-Ab-1/ GM-Tg-hg-IP0890-Ab-2 | Anti-Human GCLC monoclonal antibody | Human |
| GM-Tg-rg-IP0890-Ab-1/ GM-Tg-rg-IP0890-Ab-2 | Anti-Rat GCLC monoclonal antibody | Rat |
| GM-Tg-mg-IP0890-Ab-1/ GM-Tg-mg-IP0890-Ab-2 | Anti-Mouse GCLC monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0890-Ab-1/ GM-Tg-cynog-IP0890-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GCLC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0890-Ab-1/ GM-Tg-felg-IP0890-Ab-2 | Anti-Feline GCLC monoclonal antibody | Feline |
| GM-Tg-cang-IP0890-Ab-1/ GM-Tg-cang-IP0890-Ab-2 | Anti-Canine GCLC monoclonal antibody | Canine |
| GM-Tg-bovg-IP0890-Ab-1/ GM-Tg-bovg-IP0890-Ab-2 | Anti-Bovine GCLC monoclonal antibody | Bovine |
| GM-Tg-equg-IP0890-Ab-1/ GM-Tg-equg-IP0890-Ab-2 | Anti-Equine GCLC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0890-Ab-1/ GM-Tg-hg-IP0890-Ab-2; GM-Tg-rg-IP0890-Ab-1/ GM-Tg-rg-IP0890-Ab-2; GM-Tg-mg-IP0890-Ab-1/ GM-Tg-mg-IP0890-Ab-2; GM-Tg-cynog-IP0890-Ab-1/ GM-Tg-cynog-IP0890-Ab-2; GM-Tg-felg-IP0890-Ab-1/ GM-Tg-felg-IP0890-Ab-2; GM-Tg-cang-IP0890-Ab-1/ GM-Tg-cang-IP0890-Ab-2; GM-Tg-bovg-IP0890-Ab-1/ GM-Tg-bovg-IP0890-Ab-2; GM-Tg-equg-IP0890-Ab-1/ GM-Tg-equg-IP0890-Ab-2 |
| Products Name | Anti-GCLC monoclonal antibody |
| Format | mab |
| Target Name | GCLC |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-GCLC monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0890-Ag-1 | Recombinant multi-species GSH1/ GCLC/ GCL protein |
| ORF Viral Vector | pGMLP002985 | human GCLC Lentivirus plasmid |
| ORF Viral Vector | vGMLP002985 | human GCLC Lentivirus particle |
| ORF Viral Vector | pGMLPm003411 | mouse Gclc Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003411 | mouse Gclc Lentivirus particle |
Target information
| Target ID | GM-IP0890 |
| Target Name | GCLC |
| Gene ID | 2729,14629,25283,710508,609822,101096568,512468,100056731 |
| Gene Symbol and Synonyms | D9Wsu168e,GCL,GCLC,GCS,Ggcs-hs,GLCL,GLCL-H,GLCLC |
| Uniprot Accession | P48506,P19468 |
| Uniprot Entry Name | GSH1_HUMAN,GSH1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000001084 |
| Target Classification | N/A |
The target: GCLC, gene name: GCLC, also named as GCL, GCS, GLCL, GLCLC. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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