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Anti-IDH2 monoclonal antibody
Pre-made anti-IDH2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to IDH2/IDH2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0248-Ab-1/ GM-Tg-hg-IP0248-Ab-2 | Anti-Human IDH2 monoclonal antibody | Human |
| GM-Tg-rg-IP0248-Ab-1/ GM-Tg-rg-IP0248-Ab-2 | Anti-Rat IDH2 monoclonal antibody | Rat |
| GM-Tg-mg-IP0248-Ab-1/ GM-Tg-mg-IP0248-Ab-2 | Anti-Mouse IDH2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0248-Ab-1/ GM-Tg-cynog-IP0248-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IDH2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0248-Ab-1/ GM-Tg-felg-IP0248-Ab-2 | Anti-Feline IDH2 monoclonal antibody | Feline |
| GM-Tg-cang-IP0248-Ab-1/ GM-Tg-cang-IP0248-Ab-2 | Anti-Canine IDH2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0248-Ab-1/ GM-Tg-bovg-IP0248-Ab-2 | Anti-Bovine IDH2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0248-Ab-1/ GM-Tg-equg-IP0248-Ab-2 | Anti-Equine IDH2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0248-Ab-1/ GM-Tg-hg-IP0248-Ab-2; GM-Tg-rg-IP0248-Ab-1/ GM-Tg-rg-IP0248-Ab-2; GM-Tg-mg-IP0248-Ab-1/ GM-Tg-mg-IP0248-Ab-2; GM-Tg-cynog-IP0248-Ab-1/ GM-Tg-cynog-IP0248-Ab-2; GM-Tg-felg-IP0248-Ab-1/ GM-Tg-felg-IP0248-Ab-2; GM-Tg-cang-IP0248-Ab-1/ GM-Tg-cang-IP0248-Ab-2; GM-Tg-bovg-IP0248-Ab-1/ GM-Tg-bovg-IP0248-Ab-2; GM-Tg-equg-IP0248-Ab-1/ GM-Tg-equg-IP0248-Ab-2 |
| Products Name | Anti-IDH2 monoclonal antibody |
| Format | mab |
| Target Name | IDH2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-IDH2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0248-Ag-1 | Recombinant multi-species IDHP/ IDH2/ D2HGA2 protein |
| ORF Viral Vector | pGMLPm002194 | mouse Idh2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002194 | mouse Idh2 Lentivirus particle |
Target information
| Target ID | GM-IP0248 |
| Target Name | IDH2 |
| Gene ID | 3418,269951,361596,701480,479043,101082315,327669,100069086 |
| Gene Symbol and Synonyms | D2HGA2,E430004F23,ICD-M,IDH,IDH-2,IDH2,IDHM,IDP,IDPM,mNADP-IDH |
| Uniprot Accession | P48735,P56574,Q04467 |
| Uniprot Entry Name | IDHP_HUMAN,IDHP_RAT,IDHP_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000182054 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: IDH2, gene name: IDH2, also named as D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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