Anti-VDUP1 monoclonal antibody

Pre-made anti-VDUP1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to VDUP1/TXNIP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0163-Ab-1/ GM-Tg-hg-IP0163-Ab-2Anti-Human VDUP1/TXNIP monoclonal antibodyHuman
GM-Tg-rg-IP0163-Ab-1/ GM-Tg-rg-IP0163-Ab-2Anti-Rat VDUP1/TXNIP monoclonal antibodyRat
GM-Tg-mg-IP0163-Ab-1/ GM-Tg-mg-IP0163-Ab-2Anti-Mouse VDUP1/TXNIP monoclonal antibodyMouse
GM-Tg-cynog-IP0163-Ab-1/ GM-Tg-cynog-IP0163-Ab-2Anti-Cynomolgus/ Rhesus macaque VDUP1/TXNIP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0163-Ab-1/ GM-Tg-felg-IP0163-Ab-2Anti-Feline VDUP1/TXNIP monoclonal antibodyFeline
GM-Tg-cang-IP0163-Ab-1/ GM-Tg-cang-IP0163-Ab-2Anti-Canine VDUP1/TXNIP monoclonal antibodyCanine
GM-Tg-bovg-IP0163-Ab-1/ GM-Tg-bovg-IP0163-Ab-2Anti-Bovine VDUP1/TXNIP monoclonal antibodyBovine
GM-Tg-equg-IP0163-Ab-1/ GM-Tg-equg-IP0163-Ab-2Anti-Equine VDUP1/TXNIP monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP0163-Ab-1/ GM-Tg-hg-IP0163-Ab-2; GM-Tg-rg-IP0163-Ab-1/ GM-Tg-rg-IP0163-Ab-2;
GM-Tg-mg-IP0163-Ab-1/ GM-Tg-mg-IP0163-Ab-2; GM-Tg-cynog-IP0163-Ab-1/ GM-Tg-cynog-IP0163-Ab-2;
GM-Tg-felg-IP0163-Ab-1/ GM-Tg-felg-IP0163-Ab-2; GM-Tg-cang-IP0163-Ab-1/ GM-Tg-cang-IP0163-Ab-2;
GM-Tg-bovg-IP0163-Ab-1/ GM-Tg-bovg-IP0163-Ab-2; GM-Tg-equg-IP0163-Ab-1/ GM-Tg-equg-IP0163-Ab-2
Products NameAnti-VDUP1/TXNIP monoclonal antibody
Formatmab
Target NameVDUP1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-VDUP1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0163-Ag-1Recombinant multi-species TXNIP/ VDUP1/ ARRDC6 protein
    ORF Viral VectorpGMLV000188human TXNIP Lentivirus plasmid
    ORF Viral VectorpGMAP000591human TXNIP Adenovirus plasmid
    ORF Viral VectorvGMAP000591human TXNIP Adenovirus particle
    ORF Viral VectorvGMLV000188human TXNIP Lentivirus particle
    ORF Viral VectorpGMAD000027mouse Txnip Adenovirus plasmid
    ORF Viral VectorpGMAAV000006mouse Txnip AAV plasmid
    ORF Viral VectorvGMAD000027mouse Txnip Adenovirus particle
    ORF Viral VectorvGMAAV000006mouse Txnip AAV particle


    Target information

    Target IDGM-IP0163
    Target NameVDUP1
    Gene ID10628,56338,117514,698683,475829,101099739,506790,111773538
    Gene Symbol and Synonyms1200008J08Rik,ARRDC6,EST01027,HHCPA78,Hyplip1,Tbp-2,THIF,TXNIP,VDUP1
    Uniprot AccessionQ9H3M7,Q5M7W1
    Uniprot Entry NameTXNIP_HUMAN,TXNIP_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000265972
    Target ClassificationTumor-associated antigen (TAA)

    The target: VDUP1, gene name: TXNIP, also named as ARRDC6, EST01027, HHCPA78, THIF, VDUP1. This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.