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Anti-FUT3 monoclonal antibody
Pre-made anti-FUT3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FUT3/FUT3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0076-Ab-1/ GM-Tg-hg-IP0076-Ab-2 | Anti-Human FUT3 monoclonal antibody | Human |
| GM-Tg-rg-IP0076-Ab-1/ GM-Tg-rg-IP0076-Ab-2 | Anti-Rat FUT3 monoclonal antibody | Rat |
| GM-Tg-mg-IP0076-Ab-1/ GM-Tg-mg-IP0076-Ab-2 | Anti-Mouse FUT3 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0076-Ab-1/ GM-Tg-cynog-IP0076-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FUT3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0076-Ab-1/ GM-Tg-felg-IP0076-Ab-2 | Anti-Feline FUT3 monoclonal antibody | Feline |
| GM-Tg-cang-IP0076-Ab-1/ GM-Tg-cang-IP0076-Ab-2 | Anti-Canine FUT3 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0076-Ab-1/ GM-Tg-bovg-IP0076-Ab-2 | Anti-Bovine FUT3 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0076-Ab-1/ GM-Tg-equg-IP0076-Ab-2 | Anti-Equine FUT3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0076-Ab-1/ GM-Tg-hg-IP0076-Ab-2; GM-Tg-rg-IP0076-Ab-1/ GM-Tg-rg-IP0076-Ab-2; GM-Tg-mg-IP0076-Ab-1/ GM-Tg-mg-IP0076-Ab-2; GM-Tg-cynog-IP0076-Ab-1/ GM-Tg-cynog-IP0076-Ab-2; GM-Tg-felg-IP0076-Ab-1/ GM-Tg-felg-IP0076-Ab-2; GM-Tg-cang-IP0076-Ab-1/ GM-Tg-cang-IP0076-Ab-2; GM-Tg-bovg-IP0076-Ab-1/ GM-Tg-bovg-IP0076-Ab-2; GM-Tg-equg-IP0076-Ab-1/ GM-Tg-equg-IP0076-Ab-2 |
| Products Name | Anti-FUT3 monoclonal antibody |
| Format | mab |
| Target Name | FUT3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FUT3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0076-Ag-1 | Recombinant multi-species FUT3/ CD174/ FT3B protein |
| ORF Viral Vector | vGMLP003593 | human FUT3 Lentivirus particle |
| ORF Viral Vector | pGMLP003593 | human FUT3 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000456 | human FUT3 Lentivirus particle |
| ORF Viral Vector | pGMLV000456 | human FUT3 Lentivirus plasmid |
Target information
| Target ID | GM-IP0076 |
| Target Name | FUT3 |
| Gene ID | 2525 |
| Gene Symbol and Synonyms | CD174,FT3B,FucT-III,FUT3,LE,Les |
| Uniprot Accession | P21217 |
| Uniprot Entry Name | FUT3_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000171124 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: FUT3, gene name: FUT3, also named as CD174, FT3B, FucT-III, LE, Les. The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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