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Anti-HMGCR monoclonal antibody
Pre-made anti-HMGCR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HMGCR/HMGCR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0005-Ab-1/ GM-Tg-hg-IP0005-Ab-2 | Anti-Human HMGCR monoclonal antibody | Human |
| GM-Tg-rg-IP0005-Ab-1/ GM-Tg-rg-IP0005-Ab-2 | Anti-Rat HMGCR monoclonal antibody | Rat |
| GM-Tg-mg-IP0005-Ab-1/ GM-Tg-mg-IP0005-Ab-2 | Anti-Mouse HMGCR monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0005-Ab-1/ GM-Tg-cynog-IP0005-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HMGCR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0005-Ab-1/ GM-Tg-felg-IP0005-Ab-2 | Anti-Feline HMGCR monoclonal antibody | Feline |
| GM-Tg-cang-IP0005-Ab-1/ GM-Tg-cang-IP0005-Ab-2 | Anti-Canine HMGCR monoclonal antibody | Canine |
| GM-Tg-bovg-IP0005-Ab-1/ GM-Tg-bovg-IP0005-Ab-2 | Anti-Bovine HMGCR monoclonal antibody | Bovine |
| GM-Tg-equg-IP0005-Ab-1/ GM-Tg-equg-IP0005-Ab-2 | Anti-Equine HMGCR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0005-Ab-1/ GM-Tg-hg-IP0005-Ab-2; GM-Tg-rg-IP0005-Ab-1/ GM-Tg-rg-IP0005-Ab-2; GM-Tg-mg-IP0005-Ab-1/ GM-Tg-mg-IP0005-Ab-2; GM-Tg-cynog-IP0005-Ab-1/ GM-Tg-cynog-IP0005-Ab-2; GM-Tg-felg-IP0005-Ab-1/ GM-Tg-felg-IP0005-Ab-2; GM-Tg-cang-IP0005-Ab-1/ GM-Tg-cang-IP0005-Ab-2; GM-Tg-bovg-IP0005-Ab-1/ GM-Tg-bovg-IP0005-Ab-2; GM-Tg-equg-IP0005-Ab-1/ GM-Tg-equg-IP0005-Ab-2 |
| Products Name | Anti-HMGCR monoclonal antibody |
| Format | mab |
| Target Name | HMGCR |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HMGCR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0005-Ag-1 | Recombinant multi-species HMDH/ HMGCR/ LDLCQ3 protein |
| ORF Viral Vector | pGMLPm004787 | mouse Hmgcr Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004787 | mouse Hmgcr Lentivirus particle |
Target information
| Target ID | GM-IP0005 |
| Target Name | HMGCR |
| Gene ID | 3156,15357,25675,705479,479182,101098922,407159,100065577 |
| Gene Symbol and Synonyms | 3H3M,hmg-coa-r,HMG-CoAR,HMGCR,LDLCQ3,MYPLG,Red |
| Uniprot Accession | P04035,P51639,A7Z064 |
| Uniprot Entry Name | HMDH_HUMAN,HMDH_RAT,HMDH_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000113161 |
| Target Classification | N/A |
The target: HMGCR, gene name: HMGCR, also named as LDLCQ3. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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