Human PSEN1/ACNINV3/ AD3 ORF/cDNA clone-Lentivirus particle (NM_000021.3)
Pre-made Human PSEN1/ACNINV3/ AD3 Lentiviral expression plasmid for PSEN1 lentivirus packaging, PSEN1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.
The GM Vector Core (GMVC) specializes in custom lentivirus development and offers a range of lentivirus manufacturing solutions, leveraging state-of-the-art processes. Learn more about our services.
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Product information
Catalog No. | Product Name | lentivirus Grade | lentivirus quantity |
---|---|---|---|
vGMLV000462 | Human PSEN1 Lentivirus particle | Pilot Grade | 1.0E+8TU |
5.0E+8TU | |||
1.0E+9TU | |||
Research Grade | 1.0E+8TU | ||
5.0E+8TU | |||
1.0E+9TU | |||
GMP-like Grade | inquiry | ||
GMP Grade | inquiry |
Product Description
Catalog ID | vGMLV000462 |
Gene Name | PSEN1 |
Accession Number | NM_000021.3 |
Gene ID | 5663 |
Species | Human |
Product Type | Lentivirus particle (overexpression) |
Insert Length | 1404 bp |
Gene Alias | ACNINV3, AD3, FAD, PS-1, PS1, PSNL1, S182 |
Fluorescent Reporter | ZsGreen |
Mammalian Cell Selection | Puromyocinmyocin |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
---|---|---|
Target Antibody | GM-Tg-g-T93105-Ab | Anti-PSN1/ PSEN1/ ACNINV3 monoclonal antibody |
Target Antigen | GM-Tg-g-T93105-Ag | PSEN1 VLP (virus-like particle) |
ORF Viral Vector | pGMLV000462 | Human PSEN1 Lentivirus plasmid |
ORF Viral Vector | pGMLV000766 | Human PSEN1 Lentivirus plasmid |
ORF Viral Vector | vGMLV000462 | Human PSEN1 Lentivirus particle |
ORF Viral Vector | vGMLV000766 | Human PSEN1 Lentivirus particle |
Target information
Target ID | GM-T93105 |
Target Name | PSEN1 |
Gene ID | 5663, 19164, 696274, 29192, 101087239, 403408, 282705, 100050164 |
Gene Symbol and Synonyms | ACNINV3,AD3,Ad3h,FAD,PS-1,PS1,PSEN1,PSNL1,S182 |
Uniprot Accession | P49768 |
Uniprot Entry Name | PSN1_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Not Available |
Gene Ensembl | ENSG00000080815 |
Target Classification | Not Available |
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
About GMVC
GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.