Human PSEN1/AD3/FAD ORF/cDNA clone-Lentivirus plasmid (NM_000021.3)

SKU: pGMLV000462
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human PSEN1/AD3/FAD Lentiviral expression plasmid for PSEN1 lentivirus packaging, PSEN1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLV000462
Gene Name PSEN1
Accession Number NM_000021.3
Gene ID 5663
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 1404 bp
Gene Alias AD3,FAD,PS-1,PS1,S182
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T93105-Ab Anti-PSN1/ PSEN1/ ACNINV3 monoclonal antibody
    Target Antigen GM-Tg-g-T93105-Ag PSEN1 VLP (virus-like particle)
    ORF Viral Vector pGMLV000462 Human PSEN1 Lentivirus plasmid
    ORF Viral Vector pGMLV000766 Human PSEN1 Lentivirus plasmid
    ORF Viral Vector vGMLV000462 Human PSEN1 Lentivirus particle
    ORF Viral Vector vGMLV000766 Human PSEN1 Lentivirus particle


    Target information

    Target ID GM-T93105
    Target Name PSEN1
    Gene ID 5663, 19164, 696274, 29192, 101087239, 403408, 282705, 100050164
    Gene Symbol and Synonyms ACNINV3,AD3,Ad3h,FAD,PS-1,PS1,PSEN1,PSNL1,S182
    Uniprot Accession P49768
    Uniprot Entry Name PSN1_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Not Available
    Gene Ensembl ENSG00000080815
    Target Classification Not Available

    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]



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