Human PTEN/10q23del/BZS ORF/cDNA clone-Lentivirus particle (NM_000314)

Cat. No.: vGMLV000452

Pre-made Human PTEN/10q23del/BZS Lentiviral expression plasmid for PTEN lentivirus packaging, PTEN lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdf MSDS
pdf Datasheet

Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLV000452 Human PTEN Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLV000452
Gene Name PTEN
Accession Number NM_000314
Gene ID 5728
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 1212 bp
Gene Alias 10q23del,BZS,CWS1,DEC,GLM2,MHAM,MMAC1,PTEN1,PTENbeta,TEP1
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence 正确

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T38257-Ab Anti-PTEN/ 10q23del/ BZS monoclonal antibody
    Target Antigen GM-Tg-g-T38257-Ag PTEN VLP (virus-like particle)
    ORF Viral Vector pGMLP005649 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMLV000452 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMLV001225 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMLV002290 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMAD000006 Human PTEN Adenovirus plasmid
    ORF Viral Vector pGMLP-SPh-003 Human PTEN Lentivirus plasmid
    ORF Viral Vector pGMAP-SPh-143 Human PTEN Adenovirus plasmid
    ORF Viral Vector pGMPC000358 Human PTEN Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001526 Human PTEN Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC001692 Human PTEN Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector pGMPC004795 Human PTEN Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP005649 Human PTEN Lentivirus particle
    ORF Viral Vector vGMLV000452 Human PTEN Lentivirus particle
    ORF Viral Vector vGMLV001225 Human PTEN Lentivirus particle
    ORF Viral Vector vGMLV002290 Human PTEN Lentivirus particle
    ORF Viral Vector vGMAD000006 Human PTEN Adenovirus particle
    ORF Viral Vector vGMLP-SPh-003 Human PTEN Lentivirus particle
    ORF Viral Vector vGMAP-SPh-143 Human PTEN Adenovirus particle


    Target information

    Target ID GM-T38257
    Target Name PTEN
    Gene ID 5728, 19211, 705121, 50557, 101091813, 403832, 540786, 100062388
    Gene Symbol and Synonyms 10q23del,2310035O07Rik,A130070J02Rik,B430203M17Rik,BZS,CWS1,DEC,GLM2,MHAM,Mmac,MMAC1,PTEN,PTEN1,PTENbeta,TEP1
    Uniprot Accession P60484
    Uniprot Entry Name PTEN_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000171862
    Target Classification Tumor-associated antigen (TAA)

    This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]



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